机构：[1]Medical School, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China[2]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, 650032, Yunnan, China内科片消化内科云南省第一人民医院
Proline-rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non-receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth factor receptor (EGFR) signaling pathway. EGFR signaling pathway is a traditional carcinogenic signaling pathway, which plays a critical role in tumorigenesis and tumor progression. FAK inhibitors have been reported to fail to get the ideal anti-cancer outcomes because of activation of EGFR signaling pathway. Better understanding of Pyk2 downstream targets and interconnectivity between Pyk2 and carcinogenic EGFR signaling pathway will help finding more effective targets for clinical anti-cancer combination therapies. Thus, the interconnectivity between Pyk2 and EGFR signaling pathway, which regulates tumor development and metastasis, needs to be elucidated. In this review, we summarized the downstream targets of Pyk2 in cancers, focused on the connection between Pyk2 and EGFR signaling pathway in different
基金：
This study was partially supported by the National Natural
Science Foundation of China (grant no. 81260323).
第一作者机构：[1]Medical School, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China[2]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, 650032, Yunnan, China
通讯作者：
通讯机构：[1]Medical School, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China[2]Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, 650032, Yunnan, China
推荐引用方式(GB/T 7714)：
Shen Ting,Guo Qiang.EGFR signaling pathway occupies an important position in cancer-related downstream signaling pathways of Pyk2[J].CELL BIOLOGY INTERNATIONAL.2020,44(1):2-13.doi:10.1002/cbin.11209.
APA：
Shen, Ting&Guo, Qiang.(2020).EGFR signaling pathway occupies an important position in cancer-related downstream signaling pathways of Pyk2.CELL BIOLOGY INTERNATIONAL,44,(1)
MLA：
Shen, Ting,et al."EGFR signaling pathway occupies an important position in cancer-related downstream signaling pathways of Pyk2".CELL BIOLOGY INTERNATIONAL 44..1(2020):2-13
