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Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy

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收录情况： ◇ SCIE

作者：
Yu Tingdong[1,2] * ; He Yanan[3] * ; Chen Haitao[1] * ; Lu Xiaokai[1] ; Ni Huijing[1] ; Ma Yimin[4] ; Chen Yumei[1] ; Li Chen[2] ; Cao Run[2] ; Ma Liju[5] ; Li Zhiyao[1] ; Lei Yujie[2] ; Luo Xiaomao[1] ; Zheng Chenhong[1] ;
机构： [1]Department of Ultrasound, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, 650118, Yunnan, PR China [2]Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area, Kunming, 650118, Yunnan, PR China [3]Department of Ultrasound, The Third People′ s Hospital of Kunming, Kunming 650041, PR China [4]Inner Mongolia Medical University, Huhhot, Inner Mongolia 010000, PR China [5]Department of Medical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, PR China
出处：
DOI： 10.1016/j.phymed.2022.154311
ISSN：

摘要：
Acetaminophen (APAP) overdose represents one of the most common drug-induced liver injuries (DILI) worldwide. Oxidative damage to the hepatocytes and their resultant autophagy are the key components in the APAP-induced DILI. Echinacea purpurea polysaccharide (EPPS), the component extracted from the root of Echinacea purpurea (L.) Moench, shows various biological functions including immunoregulation and antioxidant activity.This study aimed to elucidate the protective effect of EPPS against APAP-induced DILI and the underlying mechanisms.EPPS attenuates APAP overdose induced DILI in mice and ameliorates inflammation and oxidative stress in mice with APAP overdose-induced DILI. Furthermore, EPPS protected the hepatocytes against APAP-induced liver injury by suppressing apoptosis. EPPS ameliorates APAP-induced DILI via an autophagy-dependent mechanism in vivo and increases autophagy with a reduction in oxidative stress and inflammation in vitro. Parkin knockdown prevents the autophagic-dependent manner of EPPS effects in APAP-treated hepatocytes.EPPS exhibited a strong hepatoprotective effect against APAP-induced DILI and was correlated with reduction of autophagy-dependent oxidant response, inflammation, and apoptosis. Moreover, the findings indicated that EPPS exerts its hepatoprotective effect against APAP mainly via Parkin-dependent autophagy, and the use of EPPS can serve as a promising novel therapeutic strategy for APAP-induced DILI.Copyright © 2022. Published by Elsevier GmbH.

基金：
The National Science Foundation of China (No. 82160125 to Z.C.H), The Joint Special Funds for the Department of Science and Technology of Yunnan Province Kunming Medical University (No. 202201AY070001-168,170,136,041). Yunnan Provincial Department of Education Science Research Fund Project (No.2020J0197). Science and Technology Innovation Team of Diagnosis and Treatment for Glucolipid Metabolic Diseases in Kunming Medical University (No. CXTD202106). China Postdoctoral Science Foundation (No. 2020M673593XB).
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外文
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出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 药学 1 区 全科医学与补充医学 1 区 植物科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
JCR分区：
出版当年[2021]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Ultrasound, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, 650118, Yunnan, PR China [2]Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area, Kunming, 650118, Yunnan, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yu Tingdong,He Yanan,Chen Haitao,et al.Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy[J].PHYTOMEDICINE.2022,104:doi:10.1016/j.phymed.2022.154311.
APA：
Yu Tingdong,He Yanan,Chen Haitao,Lu Xiaokai,Ni Huijing...&Zheng Chenhong.(2022).Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy.PHYTOMEDICINE,104,
MLA：
Yu Tingdong,et al."Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy".PHYTOMEDICINE 104.(2022)

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