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First-Trimester Evaluation of Cleft Lip and Palate by A Novel Two-Dimensional Sonographic Technique: A Prospective Study

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机构： [1]Department of Obstetrics, The First People\'s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province 650500, China. [2]Department of Intensive Care Unit, The Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province), Kunming, Yunnan Province 650021, China.

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Objectives To evaluate the value of the mandible transection head-side shifting method (MTHSM) by 2-dimensional sonography in the screening of fetal cleft lip and palate (CLP) during the nuchal translucency scans. Methods A total of 7,336 fetuses enrolled for first-trimester aneuploidy screening were included in this prospective study. A sequential scanning approach from the mandible transection toward the head was used for the assessment of the palate in the midsagittal, axial, and coronal sections. To observe the continuity of the palatal line, upper alveolar ridge, and primary palate. All fetuses were followed by second-trimester scans and postnatal evaluation. Results A total of 18 cases of CLP were identified in the first trimester based on this method. Out of 18, 9 (50.0%) were unilateral CLP, 4 (22.2%) were bilateral CLP, 5 (27.8%) were median CLP. There were no false-positive results found. Three were missed, but confirmed in the second-trimester anomaly scan, including 2 cases of isolated cleft palate (CP), and one of isolated cleft lip (CL). First-trimester diagnosis of CLP using MTHSM had a sensitivity of 85.7%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 99.9%. Conclusions The mandible transection head-side shifting method is feasible in assessing CLP at the time of routine first-trimester sonographic screening.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区核医学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区核医学

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出版当年[2022]版：

Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 1.1 最新[2023版] 1 最新五年平均 1.4 出版当年[2022版] 1.2 出版当年五年平均 1.288 出版前一年[2021版] 1.1 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Obstetrics, The First People\'s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province 650500, China.

通讯作者：

通讯机构： [1]Department of Obstetrics, The First People\'s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province 650500, China.

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