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Age-specific random day serum anti-Mullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey

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收录情况： ◇ SCIE

作者：
Hao Yongxiu[1,2,3,4] * ; Yang Rui[1,2,3,4] * ; Li Jia[1,2,3,4] * ; Zhou Zehong[5,6] ; Qian Weiping[7] ; Zhang Jian[8] ; Wu Ze[9] ; Jin Lei[10] ; Wu Xueqing[11] ; Zhang Cuilian[12] ; Zheng Beihong[13] ; Tan Jichun[14] ; Hao Guimin[15] ; Li Shangwei[16] ; Li Qin[1,2,3,4] ; Zheng Danni[1,2,3,4] ; Wang Yuanyuan[1,2,3,4] ; Li Rong[1,2,3,4] ; Liu Ping[1,2,3,4] ; Qiao Jie[1,2,3,4] ;
机构： [1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China [2]National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191, China [3]Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China [4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China [5]Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China [6]Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China [7]Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China [8]Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China [9]Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, China [10]Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China [11]Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Affiliate Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi, China [12]Reproductive Medical Center, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China [13]Reproductive Medicine Center, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian, China [14]Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning, China [15]Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China [16]Division of Reproductive Medical Center, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China
出处：
DOI： 10.1016/j.ajog.2022.07.029
ISSN：

摘要：
Anti-Mullerian hormone, the most reliable biomarker of ovarian reserve, is widely used in various clinical situations. Anti-Mullerian hormone levels consistently decrease with age. However, there are no standard, age-specific reference values for anti-Mullerian hormone in women of reproductive age, which limits its application.To establish age-specific anti-Mullerian hormone centile reference values for women of reproductive age.A nationwide, population-based cross-sectional survey was conducted between May 2019 and April 2021 in 15 provinces/municipalities in mainland China. A total of 10,053 eligible women aged 20-49 years were selected using a multistage stratified sampling procedure. Women who were pregnant, had undergone ovarian surgery, took hormone drugs in the past 3 months, or had an anti-Mullerian hormone outlier value were excluded in establishing anti-Mullerian hormone centile reference values. Serum anti-Mullerian hormone concentrations were measured using ultra-sensitive, two-site enzyme-linked immunosorbent assays (Ansh Lab) in the Reproductive Endocrinology Laboratory of Peking University Third Hospital. Generalized additive models for location scale and shape with the Box-Cox t original distribution were used to estimate the fitted anti-Mullerian hormone centile reference values.A total of 9,112 eligible women aged 21-49 years were included in the fitting model. The fitted 50th (2.5th-97.5th) centile of anti-Mullerian hormone values for women aged 21, 25, 30, 35, 40, 45, and 49 years were 4.83 (0.79-18.41), 4.47 (0.72-16.58), 3.67 (0.50-13.82), 2.59 (0.24-10.35), 1.35 (0.05-6.68), 0.33 (<0.01-3.40), and 0.04 (<0.01-1.77) ng/ml, respectively. The population-based decline rate in anti-Mullerian hormone accelerated with increasing age, especially age over 35 years. The magnitude of decline of the 25th anti-Mullerian hormone centile curve was greater than that of the 75th centile curve.We established age-specific anti-Mullerian hormone centile reference values for women of reproductive age based on a large representative sample of the general population and described anti-Mullerian hormone changes. Our findings may facilitate anti-Mullerian hormone application in clinical practices.Copyright © 2022. Published by Elsevier Inc.

基金：
National Key Research and Development Program (No. 51 2018YFC1002106) and Beijing Municipal Science and Technology Commission 52 (Z191100006619085).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 妇产科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 妇产科学
JCR分区：
出版当年[2021]版：
Q1 OBSTETRICS & GYNECOLOGY
最新[2023]版：
Q1 OBSTETRICS & GYNECOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China [2]National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191, China [3]Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China [4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
共同第一作者：
通讯作者：
通讯机构： [1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China [2]National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191, China [3]Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China [4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
推荐引用方式(GB/T 7714)：
Hao Yongxiu,Yang Rui,Li Jia,et al.Age-specific random day serum anti-Mullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey[J].AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.2022,227(6):doi:10.1016/j.ajog.2022.07.029.
APA：
Hao Yongxiu,Yang Rui,Li Jia,Zhou Zehong,Qian Weiping...&Qiao Jie.(2022).Age-specific random day serum anti-Mullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey.AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,227,(6)
MLA：
Hao Yongxiu,et al."Age-specific random day serum anti-Mullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey".AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 227..6(2022)

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