Cubital tunnel syndrome is a peripheral nerve compression disease, which is caused by the reduction of cubital tunnel space and the compression of ulnar nerve in the cubital tunnel. The main clinical symptoms were numbness and hypoesthesia in the distribution area of ulnar nerve.We report a case of complex cubital tunnel syndrome caused by an old lateral humeral condyle fracture combined with gouty stone compression. Before surgery, the patient's left hypothenar, ring finger and little finger were numb, decreased grip strength, positive paper clamp test. And finger numbness and finger weakness were significantly improved after ulnar nerve release combined with Gout stone resection.In this case report, the elbow joint deformity caused by old lateral humeral condyle fracture was not treated surgically. Only ulnar nerve release combined with Gout stone resection was performed, and the patient's symptoms were significantly relieved.In this case report, for the treatment of cubital tunnel syndrome caused by multiple causes, we only need to find out the main causes of clinical symptoms and targeted treatment, which can not only reduce surgical trauma, but also achieve good treatment results. Its treatment method and treatment result, hoping to provide reference experience forthe diagnosis and treatment of similar diseases.Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.