机构：[1]National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.[2]Department of Nephrology, Shanghai Tenth People's Hospital, Shanghai, 200072, China.[3]Center for Nephrology and Metabolomics, Tongji University School of Medicine, Shanghai, 200072, China.[4]Department of Medical Imaging, Jinling Hospital, Southern Medical University Clinical Medical College, Nanjing, Jiangsu Province, 210002, China.[5]Department of MRI, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, China.医技片磁共振科云南省第一人民医院[6]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.
Transplant renal artery stenosis (TRAS) has been shown to reduce kidney perfusion leading to post-operative hypertension. We aimed to measure the perfusion and oxygenation changes in TRAS with arterial spin labeling (ASL) and blood oxygen level-dependent (BOLD) imaging, respectively.In this single-center prospective study, a total of 7 patients with TRAS and 7 age- and sex-matched normal kidney transplant recipients underwent both ASL and BOLD imaging. Moreover, measurements of ASL and BOLD were also performed in 5 patients after successful angioplasty for TRAS.Allograft cortical perfusion as measured by ASL in the TRAS group was significantly decreased as compared with normal control group (129.9±46.6ml/100g vs. 202.4±47.7ml/100g, P = 0.01). Interestingly, allograft oxygenation as indicated by R2* derived from BOLD in both the cortex (16.42±1.90 Hz vs. 18.25±4.34 Hz, P = 0.33) and the medulla (30.34±2.35 Hz vs. 30.43±6.85 Hz, P = 0.97) showed no statistical difference between the TRAS and normal control group. In addition, both cortical and medullary oxygenation remained unchanged despite significantly improved cortical perfusion in those undergone successful angioplasty.Cortical and medullary oxygenation were preserved in the presence of reduced allograft perfusion in clinically significant TRAS. Prospective larger studies are needed to conclusively establish perfusion and oxygenation changes in TRAS. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
National Natural Science Foundation of China grants
(81570681) and (BWS20J001). Dr. Wang is supported by National Natural
Science Foundation of China grants (82000731).
第一作者机构：[1]National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.
共同第一作者：
通讯作者：
通讯机构：[1]National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.[2]Department of Nephrology, Shanghai Tenth People's Hospital, Shanghai, 200072, China.[3]Center for Nephrology and Metabolomics, Tongji University School of Medicine, Shanghai, 200072, China.[*1]National Clinical Research Center of Kidney Diseases, Jinling Clinical Medical College of Nanjing Medical University, 305 East Zhongshan Road, Xuanwu District, Nanjing, Jiangsu 210002, China[*2]National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China[*3]Department of Nephrology, Shanghai Tenth People's Hospital, Shanghai, 200072, China
推荐引用方式(GB/T 7714)：
Li Xue,Wang Wei,Cheng Dongrui,et al.Perfusion and oxygenation in allografts with transplant renal artery stenosis: evaluation with functional magnetic resonance imaging[J].CLINICAL TRANSPLANTATION.2022,36(11):doi:10.1111/ctr.14806.
APA：
Li Xue,Wang Wei,Cheng Dongrui,Yu Yuanmeng,Wu Qianqian...&Wen Jiqiu.(2022).Perfusion and oxygenation in allografts with transplant renal artery stenosis: evaluation with functional magnetic resonance imaging.CLINICAL TRANSPLANTATION,36,(11)
MLA：
Li Xue,et al."Perfusion and oxygenation in allografts with transplant renal artery stenosis: evaluation with functional magnetic resonance imaging".CLINICAL TRANSPLANTATION 36..11(2022)
