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Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity

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收录情况： ◇ SCIE

作者：
Zhang Baiyu[1] * ; Yin Saige[4] * ; Guo Caifen[1] * ; Gao Zhenhua[1] ; Li Tonghai[2] ; Lee Wenhui[3] ; Shen Jihong[1] ; Yang Xinwang[4] ;
机构： [1]First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China [2]Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan 650500, China [3]Key Laboratory of Animal Models and Human Disease Mechanisms, Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China [4]Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China
出处：
DOI： 10.1016/j.jim.2022.113343
ISSN：

摘要：
Lipopolysaccharide (LPS) is a major pathogen-associated pattern molecule that can initiate lethal sepsis. Bioactive peptides in amphibian skin secretions, especially antimicrobial peptides, are essential components of the host immune system and help fight the microbial invasion. In this study, two peptides: peptide 1 (KINRKGPRPPG) and peptide 2 (INRKGPRPPG) were isolated, from skin secretions of the Chinese red belly frog (Bombina maxima). After stimulation with LPS, synthetic peptide 1 showed direct LPS-binding activity, low cytotoxicity, immunoregulatory functions in vitro, and neutralizing LPS effects in animal models. Thus, natural peptide 1 exhibits potential as an ideal candidate against LPS.Copyright © 2022. Published by Elsevier B.V.

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外文
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出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 生化研究方法
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 生化研究方法 4 区 免疫学
JCR分区：
出版当年[2021]版：
Q4 BIOCHEMICAL RESEARCH METHODS Q4 IMMUNOLOGY
最新[2023]版：
Q4 BIOCHEMICAL RESEARCH METHODS Q4 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
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推荐引用方式(GB/T 7714)：
Zhang Baiyu,Yin Saige,Guo Caifen,et al.Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity[J].JOURNAL OF IMMUNOLOGICAL METHODS.2022,509:113343.doi:10.1016/j.jim.2022.113343.
APA：
Zhang Baiyu,Yin Saige,Guo Caifen,Gao Zhenhua,Li Tonghai...&Yang Xinwang.(2022).Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity.JOURNAL OF IMMUNOLOGICAL METHODS,509,
MLA：
Zhang Baiyu,et al."Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity".JOURNAL OF IMMUNOLOGICAL METHODS 509.(2022):113343

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