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Characteristic dysbiosis in gout and the impact of a uric acid-lowering treatment, febuxostat on the gut microbiota

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [1]Rheumatology Department, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, China [2]State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China [3]Rheumatology Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China [4]Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China [5]Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China

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Gut dysbiosis is suggested to play a critical role in the pathogenesis of gout. The aim of our study was to identify the characteristic dysbiosis of the gut microbiota in gout patients and the impact of a commonly used uric acid-lowering treatment, febuxostat on gut microbiota in gout. 16S ribosomal RNA sequencing and metagenomic shotgun sequencing was performed on fecal DNA isolated from 38 untreated gout patients, 38 gout patients treated with febuxostat, and 26 healthy controls. A restriction of gut microbiota biodiversity was detected in the untreated gout patients, and the alteration was partly restored by febuxostat. Biochemical metabolic indexes involved in liver and kidney metabolism were significantly associated with the gut microbiota composition in gout patients. Functional analysis revealed that the gut microbiome of gout patients had an enriched function on carbohydrate metabolism but a lower potential for purine metabolism, which was comparatively enhanced in the febuxostat treated gout patients. A classification microbial model obtained a high mean area under the curve up to 0.973. Therefore, gut dysbiosis characterizings gout could potentially serve as a noninvasive diagnostic tool for gout and may be a promising target of future preventive interventions.Copyright © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

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出版当年[2021]版：

大类 | 2 区生物

小类 | 2 区遗传学 3 区生化与分子生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学 3 区遗传学

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出版当年[2020]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 GENETICS & HEREDITY

最新[2023]版：

Q1 GENETICS & HEREDITY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 6.6 最新[2023版] 5.8 最新五年平均 4.275 出版当年[2020版] 5.223 出版当年五年平均 5.065 出版前一年[2019版] 5.723 出版后一年[2021版]

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第一作者机构： [1]Rheumatology Department, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, China

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通讯机构： [1]Rheumatology Department, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, China [5]Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China

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