机构：[1]Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.[2]Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.[3]Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.[4]Shenzhen Evergreen Medical Institute, Shenzhen, China.[5]College of Pharmacy, Jinan University, Guangzhou, China.[6]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.[7]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China.[8]Beijing Anzhen Hospital, Capital Medical University, Beijing, China.首都医科大学附属安贞医院[9]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China.[10]Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming, China.昆明医科大学附属第一医院[11]Institute for Biomedicine, Anhui Medical University, Hefei, China.[12]Department of Preventive Medicine, School of Public Health &Management, Wenzhou Medical University, Wenzhou, China.[13]Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease ,State Key Laboratory for Organ Failure Research, Guangzhou, China.[14]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China.
Tobacco smoking is a major known risk factor for lung cancer. While micronutrients, especially those involved in maintaining DNA integrity and regulating gene expression, may be protective, research on this association is limited. This report aimed to investigate associations of total folate, 5-methyltetrahydrofolate (5-mTHF) and vitamin B12 with incident risk of lung cancer, and whether the associations vary by smoking status. A nested case-control study with 490 incident lung cancer cases and 490 controls matched by age (±1 year), sex, residence, and center, drawn from a community-based prospective study in China, was conducted from 2016 to 2019. 5-mTHF accounted for the majority of total folate. Only 4.4% had detectable unmetabolized folic acid. Lung cancer cases had lower levels of 5-mTHF compared to controls. There was an inverse, non-linear association between 5-mTHF and lung cancer, which persisted after adjustment for covariables (P for trend=0.001). Compared to the lowest 5-mTHF quartile, those in higher quartiles had lower risks of lung cancer: second quartile OR=0.65; 95% CI: 0.45-0.93; third quartile OR=0.50; 95% CI: 0.34-0.74; fourth quartile OR=0.56; 95% CI: 0.38-0.83. This inverse association was more pronounced among ever smokers; consistently, the highest risk of lung cancer (OR=3.21, 95% CI:1.97-5.24) was observed among ever smokers with low 5-mTHF levels compared to participants who never smoked and had higher 5-mTHF levels. Vitamin B12 was not associated with lung cancer risk. In this sample of Chinese adults without confounding by unmetabolized folic acid, higher levels of 5-mTHF were associated with lower risk of incident lung cancer. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
This work was supported by the National Key Research and Development Program: The key technology of
palliative care and nursing for cancer patients (2017YFC1309200).
第一作者机构：[1]Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[6]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.[7]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China.[14]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China.[*1]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China
推荐引用方式(GB/T 7714)：
Yaping Wei,Benjamin Xu,Qiangqiang He,et al.Serum total folate, 5-methyltetrahydrofolate and vitamin B12 concentrations on incident risk of lung cancer[J].INTERNATIONAL JOURNAL OF CANCER.2023,152(6):1095-1106.doi:10.1002/ijc.34307.
APA：
Yaping Wei,Benjamin Xu,Qiangqiang He,Ping Chen,Qi Zhang...&Hanping Shi.(2023).Serum total folate, 5-methyltetrahydrofolate and vitamin B12 concentrations on incident risk of lung cancer.INTERNATIONAL JOURNAL OF CANCER,152,(6)
MLA：
Yaping Wei,et al."Serum total folate, 5-methyltetrahydrofolate and vitamin B12 concentrations on incident risk of lung cancer".INTERNATIONAL JOURNAL OF CANCER 152..6(2023):1095-1106
医学