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Long-term oncological prognosis after curative-intent liver resection for hepatocellular carcinoma in the young versus the elderly: multicentre propensity score-matching study

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Pu Jia-Le[1] * ; Chen Zhong[1] ; Yao Lan-Qing[2] ; Feng Ji-Ye[3] ; Diao Yong-Kang[4] ; Guan Ming-Cheng[5] ; Li Ju-Dong[6] ; Chen Zheng-Liang[7] ; Zhou Ya-Hao[8] ; Wang Hong[9] ; Gu Wei-Min[10] ; Li Jie[11] ; Li Chao[2] ; Wang Ming-Da[2] ; Zhu Hong[5] ; Liang Ying-Jian[7] ; Shen Feng[2] ; Pawlik Timothy M[12] ; Lau Wan Yee[2,13] ; Yang Tian[2,4,*1] ;
机构： [1]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. [2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. [3]Department of Hepatobiliary &amp [4]Pancreatic Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China. [4]Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. [5]Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China. [6]Department of Pancreatic-biliary Surgery, Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. [7]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. [8]Department of Hepatobiliary Surgery, Pu'er People's Hospital, Pu'er, Yunnan, China. [9]Department of General Surgery, Liuyang People's Hospital, Liuyang, Hunan, China. [10]The First Department of General Surgery, The Fourth Hospital of Harbin, Harbin, Heilongjiang, China. [11]Department of Hepatobiliary Surgery, Fuyang People's Hospital, Fuyang, Anhui, China. [12]Department of Surgery, Ohio State University, Wexner Medical Center, Columbus, Ohio, USA. [13]Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
出处：
DOI： 10.1093/bjsopen/zrab145
ISSN：

摘要：
Hepatocellular carcinoma (HCC) is the most common malignancy in the elderly worldwide, but it is also common among younger individuals in areas with endemic hepatitis B virus infection. The differences in long-term oncological prognosis of young versus elderly patients after R0 liver resection for HCC were explored in this study.Using a Chinese multicentre database, consecutive patients who underwent R0 liver resection for HCC between 2007 and 2019 were analysed retrospectively. After excluding middle-aged (36-69 years old) patients, overall survival (OS), cancer-specific survival (CSS), and recurrence were compared between young (35 years or younger) and elderly (70 years or older) patients using propensity score matching (PSM).Among 531 enrolled patients, there were 192 (36.2 per cent) and 339 (63.8 per cent) patients categorized as young and elderly respectively. PSM created 140 pairs of matched patients. In the PSM cohort, 5-year OS was comparable for young versus elderly patients (51.7 versus 52.3 per cent, P = 0.533). Young patients, however, had a higher 5-year cumulative recurrence rate (62.1 versus 51.6 per cent, P = 0.011) and a worse 5-year CSS rate (54.0 versus 64.3 per cent, P = 0.034) than elderly patients. On multivariable Cox regression analyses, young patient age remained independently associated with an increased recurrence rate (hazard ratio 1.62, P = 0.016) and a decreased CSS rate (hazard ratio 1.69, P = 0.021) compared with older age.Following R0 liver resection for HCC, younger patients were at a higher risk of recurrence, and elderly patients had a better CSS rate. Thus, enhanced surveillance for HCC recurrence should be implemented for young patients.© The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd.

基金：
This study was supported by the National Natural Science Foundation of China (no. 81972726).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 外科
JCR分区：
出版当年[2021]版：
Q1 SURGERY
最新[2023]版：
Q1 SURGERY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
通讯作者：
通讯机构： [2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. [4]Pancreatic Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China. [4]Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. [*1]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), No. 225, Changhai Road, Shanghai 200438, China
推荐引用方式(GB/T 7714)：
Pu Jia-Le,Chen Zhong,Yao Lan-Qing,et al.Long-term oncological prognosis after curative-intent liver resection for hepatocellular carcinoma in the young versus the elderly: multicentre propensity score-matching study[J].BJS OPEN.2022,6(1):doi:10.1093/bjsopen/zrab145.
APA：
Pu Jia-Le,Chen Zhong,Yao Lan-Qing,Feng Ji-Ye,Diao Yong-Kang...&Yang Tian.(2022).Long-term oncological prognosis after curative-intent liver resection for hepatocellular carcinoma in the young versus the elderly: multicentre propensity score-matching study.BJS OPEN,6,(1)
MLA：
Pu Jia-Le,et al."Long-term oncological prognosis after curative-intent liver resection for hepatocellular carcinoma in the young versus the elderly: multicentre propensity score-matching study".BJS OPEN 6..1(2022)

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