The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV-A71 vaccination in Kunming, China, 2017-2020
机构：[1]Department of Infectious Diseases, Kunming Children’s Hospital, The Afliated Children’s Hospital of KunmingMedical University, Institute of Pediatric Disease Research in Yunnan, Kunming 650228, People’s Republic ofChina[2]Department of Pathology, Kunming Children’s Hospital, The Afliated Children’s Hospital of KunmingMedical University, Institute of Pediatric Disease Research in Yunnan, Kunming 650228, People’s Republicof China[3]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic ofChina[4]Department of Stomatology, The Afliated Hospital of Yunnan Normal University, Kunming, People’sRepublic of China[5]The First Department of Hepatopancreatobiliary Surgery, Afliated Calmette Hospital ofKunming Medical University and The First People’s Hospital of Kunming City, Liver Transplantation Center of OrganTransplantation Institute of Yunnan Province, Kunming, People’s Republic of China[6]Weather Modifcation Centerof Yunnan Province, Kunming, People’s Republic of China[7]Weifang Center for Disease Control and Prevention,Shandong, People’s Republic of China
After vaccination with enterovirus 71 (EV-A71), the prevalence of hand-foot-and-mouth disease (HFMD) remained high, and the spatial-temporal distribution of enteroviruses changed. Therefore, it is essential to define the temporal features, spatial distributions, and epidemiological and etiological characteristics of HFMD in Kunming. Between 2017 and 2020, a total of 36,540 children were diagnosed with HFMD in Kunming, including 32,754 children with enterovirus-positive clinical samples. Demographic, geographical, epidemiological and etiological data of the cases were acquired and analyzed. Other enteroviruses replaced EV-A71, and the incidence of EV-A71 decreased dramatically, whereas coxsackievirus A6 (CV-A6) and coxsackievirus A16 (CV-A16) had substantial outbreaks in 2018 and 2019, respectively. The major and minor peaks all extended for 2-4 months compared to before vaccination with the EV-A71 vaccine. From 2019 to 2020, CV-A6, as the predominant serotype, showed only a single peak. Although a high incidence of HFMD was observed in Guandu, Chenggong and Xishan, the annual incidence of different enterovirus serotypes was different in different regions. In 2017, other enteroviruses were most prevalent in Shilin. In 2018, CV-A16 and CV-A6 were most prevalent in Luquan and Shilin, respectively. In 2019, CV-A16 was most prevalent in Jinning. In 2020, CV-A6 and coxsackievirus A10 (CV-A10) were most prevalent in Luquan and Shilin, respectively. Meanwhile, the epidemic cycle of CV-A6 and CV-A16 was only 1 year, and CV-A10 and other enteroviruses were potential risk pathogens. The spatial and temporal distribution of HFMD varies at different scales, and the incidence of HFMD associated with different pathogens has obvious regional differences and seasonal trends. Therefore, research on multivalent combined vaccines is urgently needed, and proper preventive and protective measures could effectively control the incidence of HFMD-like diseases.
基金：
Kunming "Spring City Plan" high-level talent training project, Kunming municipal government "spring city famous doctor" special project [2020-23]; Kunming Science and technology planning project [2019-1-S-25318000001241]; Kunming health and Family Planning Commission Project [2019-SW-33]; Yunnan Province's reserve medical talents project [H-2019002]; Kunming Medical University Applied Basic Research Joint Special Project [202001AY070001-170]
第一作者机构：[1]Department of Infectious Diseases, Kunming Children’s Hospital, The Afliated Children’s Hospital of KunmingMedical University, Institute of Pediatric Disease Research in Yunnan, Kunming 650228, People’s Republic ofChina[3]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic ofChina
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pathology, Kunming Children’s Hospital, The Afliated Children’s Hospital of KunmingMedical University, Institute of Pediatric Disease Research in Yunnan, Kunming 650228, People’s Republicof China[3]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic ofChina
推荐引用方式(GB/T 7714)：
MeifenWang,Tao Chen,Junchao Peng,et al.The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV-A71 vaccination in Kunming, China, 2017-2020[J].SCIENTIFIC REPORTS.2022,12(1):doi:10.1038/s41598-022-21312-2.
APA：
MeifenWang,Tao Chen,Junchao Peng,Yunjiao Luo,Lijiang Du...&Jiwei Li.(2022).The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV-A71 vaccination in Kunming, China, 2017-2020.SCIENTIFIC REPORTS,12,(1)
MLA：
MeifenWang,et al."The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV-A71 vaccination in Kunming, China, 2017-2020".SCIENTIFIC REPORTS 12..1(2022)
