机构：[1]Department of Gastrointestinal Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan,[2]The First Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan[3]The Third Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan,[4]Institute of Genetics, College of Life Sciences, Shanghai Normal University, Shanghai[5]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming[6]Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Previous studies have shown that intratumoral heterogeneity (ITH) is associated with poor clinical outcomes and is thought to be a mechanism of resistance to chemotherapy and radiotherapy.We aimed to determine how ITH affects the response to drug therapy in breast cancer (BC).We assessed ITH using mutated allele tumor heterogeneity (MATH) data from BC patients in the TCGA database.The study enrolled 515 patients with BC treated with chemotherapy from the TCGA database who had available data on survival, whole-exome sequencing, and genome-wide transcriptome sequencing. Additionally, 399 MSK-BRCA cohort patients were treated with chemotherapy.All statistical analyses were conducted using R. All comparisons were made using the two-sided Mann-Whitney test, Pearson's Chi-squared test, and the Kruskal-Wallis test. Statistical significance was defined as P values less than 0.05 (*P < 0.05). The survival package in R was used to conduct the analysis.Additional analysis was performed on 515 BC patients receiving adjuvant chemotherapy. MATH was associated with overall survival (OS) in multivariate analysis (hazard ratio (HR), 1.432; 95% confidence interval, 1.073-1.913; P = 0.015). Pathway enrichment and immune cell analysis revealed that the low MATH group had significantly higher infiltration of 24 different types of immune cells than the high MATH group.Individuals with low MATH scores had a longer OS than those with high MATH scores. Immune responses were significantly enhanced in breast cancer patients with low MATH scores.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Gastrointestinal Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan,
通讯作者：
通讯机构：[3]The Third Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan,[*1]The Third Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, China.
推荐引用方式(GB/T 7714)：
Li Yang,Wang Maohua,Yang Siyuan,et al.Intratumoral heterogeneity contributes to the chemotherapy prognosis of breast cancer[J].Journal of cancer research and therapeutics.2022,18(5):1268-1275.doi:10.4103/jcrt.jcrt_1166_21.
APA：
Li Yang,Wang Maohua,Yang Siyuan,Kuang Licheng,Tao Xinling...&Zhang Ji.(2022).Intratumoral heterogeneity contributes to the chemotherapy prognosis of breast cancer.Journal of cancer research and therapeutics,18,(5)
MLA：
Li Yang,et al."Intratumoral heterogeneity contributes to the chemotherapy prognosis of breast cancer".Journal of cancer research and therapeutics 18..5(2022):1268-1275
