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Vasicine alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis and passive cutaneous anaphylaxis in BALB/c mice

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机构: [1]College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China [2]The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, People's Republic of China [3]School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China
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关键词: Atopic dermatitis Vasicine Th2 cytokine Mast cell Passive cutaneous anaphylaxis

摘要:
Atopic dermatitis (AD), a type of skin inflammation, is associated with immune response mediated by T-helper 2 (Th2) cells, and mast cells. Vasicine is an alkaloid isolated from Adhatoda vasica, a popular Ayurvedic herbal medicine used for treating inflammatory conditions. In the present study, the anti-AD effects of vasicine were evaluated on 2,4-dinitrochlorobenzene-induced AD-like skin lesions in BALB/c mice. The potential anti-allergic effects of vasicine were also assessed using the passive cutaneous anaphylaxis (PCA) test. The results showed that the oral administration of vasicine improved the severity of AD-like lesional skin by decreasing histopathological changes and restoring epidermal thickness. Vasicine also inhibited the infiltration of mast cells in the skin and reduced the levels of pro-Th2 and Th2 cytokines as well as immunoglobulin E in the serum. Finally, vasicine inhibited the expression of pro-Th2 and Th2 cytokines in skin tissues, indicating the therapeutic potential of vasicine for AD.Copyright © 2022 Elsevier Inc. All rights reserved.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
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第一作者机构: [1]College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China
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通讯机构: [1]College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China [3]School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China [*1]College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China
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