资源类型：
期刊
Pubmed体系：
Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
文章类型：
论著
机构：
[1]Department of Biochemistry, College of Medicine, Yichun University, Yichun, Jiangxi 336000, China.
[2]Department of Clinical Medicine, Dali University, Dali, Yunnan 671003, China.
[3]Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA
[4]Department of Neurology, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China.
ISSN：
0041-008X
摘要：
Chronic exposure to arsenic promotes lung cancer. Human studies have identified immunosuppression as a risk factor for cancer development. The immune checkpoint pathway of Programmed cell death 1 ligand (PD-L1) and its receptor (programmed cell death receptor 1, PD-1) is the most studied mechanism of immunosuppression. We have previously shown that prolonged arsenic exposure induced cell transformation of BEAS-2B cells, a human lung epithelial cell line. More recently our study further showed that arsenic induced PD-L1 up-regulation, inhibited T cell effector function, and enhanced lung tumor formation in the mice. In the current study, using arsenic-induced BEAS-2B transformation as a model system we investigated the mechanism underlying PD-L1 up-regulation by arsenic. Our data suggests that Lnc-DC, a long non-coding RNA, and signal transducer and activator of transcription 3 (STAT3) mediates PD-L1 up-regulation by arsenic.Copyright © 2021. Published by Elsevier Inc.
PubmedID：
34953898
中科院(CAS)分区：
出版当年[2022]版：
大类
|
3 区
医学
小类
|
2 区
毒理学
2 区
药学
最新[2023]版：
大类
|
3 区
医学
小类
|
2 区
毒理学
3 区
药学
第一作者：
Wang Hongsen
第一作者机构：
[1]Department of Biochemistry, College of Medicine, Yichun University, Yichun, Jiangxi 336000, China.
共同第一作者：
Li Jiaqi
通讯作者：
Cui Jiajun
推荐引用方式(GB/T 7714)：
Wang Hongsen,Li Jiaqi,Xu Wenhua,et al.The mechanism underlying arsenic-induced PD-L1 upregulation in transformed BEAS-2B cells[J].Toxicology and applied pharmacology.2022,435:115845.doi:10.1016/j.taap.2021.115845.
APA：
Wang Hongsen,Li Jiaqi,Xu Wenhua,Li Chunming,Wu Kuaiying...&Cui Jiajun.(2022).The mechanism underlying arsenic-induced PD-L1 upregulation in transformed BEAS-2B cells.Toxicology and applied pharmacology,435,
MLA：
Wang Hongsen,et al."The mechanism underlying arsenic-induced PD-L1 upregulation in transformed BEAS-2B cells".Toxicology and applied pharmacology 435.(2022):115845
