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Structural and Functional Abnormalities of Olfactory-Related Regions in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease

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资源类型：
Pubmed体系：
作者：
Chen Ben[1] * ; Wang Qiang[1,2] * ; Zhong Xiaomei[1] * ; Mai Naikeng[1] ; Zhang Min[1] ; Zhou Huarong[1] ; Haehner Antje[3] ; Chen Xinru[1] ; Wu Zhangying[1] ; Auber Lavinia Alberi[4,5] ; Rao Dongping[1] ; Liu Wentao[1] ; Zheng Jinhong[6] ; Lin Lijing[6] ; Li Nanxi[6] ; Chen Sihao[6] ; Chen Bingxin[6] ; Hummel Thomas[3] ; Ning Yuping[1,7,8,*1] ;
机构： [1]Memory Clinic, Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong Province, China. [2]Department of Geriatric Psychiatry, The Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan Province, China. [3]Smell and Taste Clinic, Department of Otorhinolaryngology, Technische University Dresden, Dresden, Germany. [4]Department of Medicine, University of Fribourg, Fribourg, Switzerland. [5]Swiss Integrative Center of Human Health, Fribourg, Switzerland. [6]Guangzhou Medical University, Guangzhou, Guangdong Province, China. [7]The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China. [8]Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
出处：
DOI： 10.1093/ijnp/pyab091
ISSN：

摘要：
Odor identification (OI) dysfunction is an early marker of Alzheimer's disease (AD), but it remains unclear how olfactory-related regions change from stages of subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to AD dementia.Two hundred and sixty-nine individuals were recruited in the present study. The olfactory-related regions were defined as the regions of interest, and the grey matter volume (GMV), low-frequency fluctuation, regional homogeneity (ReHo), and functional connectivity (FC) were compared for exploring the changing pattern of structural and functional abnormalities across AD, MCI, SCD, and normal controls.From the SCD, MCI to AD groups, the reduced GMV, increased low-frequency fluctuation, increased ReHo, and reduced FC of olfactory-related regions became increasingly severe, and only the degree of reduced GMV of hippocampus and caudate nucleus clearly distinguished the 3 groups. SCD participants exhibited reduced GMV (hippocampus, etc.), increased ReHo (caudate nucleus), and reduced FC (hippocampus-hippocampus and hippocampus-parahippocampus) in olfactory-related regions compared with normal controls. Additionally, reduced GMV of the bilateral hippocampus and increased ReHo of the right caudate nucleus were associated with OI dysfunction and global cognitive impairment, and they exhibited partially mediated effects on the relationships between OI and global cognition across all participants.Structural and functional abnormalities of olfactory-related regions present early with SCD and deepen with disease severity in the AD spectrum. The hippocampus and caudate nucleus may be the hub joining OI and cognitive function in the AD spectrum.© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

基金：
the National Natural Science Foundation of China (nos. 81701341 and 82101508), the Guangzhou Municipal Psychiatric Diseases Clinical Transformation Laboratory (no. 201805010009), the Key Laboratory for Innovation Platform Plan, the Science and Technology Program of Guangzhou, China, the Science and Technology Plan Project of Guangdong Province (no. 2019B030316001), and the National Key Research and Development Program of China (no. 2016YFC0906300).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 药学 2 区 神经科学 2 区 精神病学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 神经科学 2 区 药学 2 区 精神病学 3 区 临床神经病学
第一作者：
第一作者机构： [1]Memory Clinic, Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong Province, China.
共同第一作者：
通讯作者：
通讯机构： [1]Memory Clinic, Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong Province, China. [7]The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China. [8]Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. [*1]Mingxin Road, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong Province, China
推荐引用方式(GB/T 7714)：
Chen Ben,Wang Qiang,Zhong Xiaomei,et al.Structural and Functional Abnormalities of Olfactory-Related Regions in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease[J].The international journal of neuropsychopharmacology.2022,25(5):361-374.doi:10.1093/ijnp/pyab091.
APA：
Chen Ben,Wang Qiang,Zhong Xiaomei,Mai Naikeng,Zhang Min...&Ning Yuping.(2022).Structural and Functional Abnormalities of Olfactory-Related Regions in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease.The international journal of neuropsychopharmacology,25,(5)
MLA：
Chen Ben,et al."Structural and Functional Abnormalities of Olfactory-Related Regions in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease".The international journal of neuropsychopharmacology 25..5(2022):361-374

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