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The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish

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Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：重点期刊

作者：
Wang Xinxin[1,3] * ; Ma Xin[1,3] * ; Wei Gaobo[2,3] * ; Ma Weirui[3,4] ; Zhang Zhen[5] ; Chen Xuepeng[1] ; Gao Lei[1] ; Liu Zhenbo[1] ; Yuan Yue[3,4] ; Yi Lizhi[1,3] ; Wang Jun[6] ; Tokumoto Toshinobu[6] ; Huang Junjiu[5] ; Chen Dahua[2,3] ; Zhang Jian[3,4,7] ; Liu Jiang[1,3,8] ;
机构： [1]CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences /China National Center for Bioinformation, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]University of Chinese Academy of Sciences, Beijing 100049, China [4]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academyof Sciences, Beijing 100101, China [5]Key Laboratory of Reproductive Medicine of Guangdong Province, the First Affiliated Hospital and School of Life Sciences,Sun Yat-sen University, Guangzhou 510275, China [6]Integrated Bioscience Section, Graduate School of Science and Technology, National University Corporation Shizuoka University, Shizuoka 422-8529, Japan [7]State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Center for Life Sciences, School ofLife Sciences, Yunnan University, Kunming 650091, China [8]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China
出处：
DOI： 10.1016/j.gpb.2020.10.004
ISSN：

摘要：
DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been shown to be involved the regulation of gene expression and embryo development. However, it remains unclear how DNA methylation regulates sexual development, especially in species without sex chromosomes. To determine this, we utilized zebrafish to investigate DNA methylation reprogramming during juvenile germ cell development and adult female-to-male sex transition. We revealed that primordial germ cells (PGCs) undergo significant DNA methylation reprogramming during germline development and set to an oocyte/ovary-like pattern at 9 days post fertilization (9 dpf). When DNA methyltransferase (DNMT) activity in juveniles was blocked after 9 dpf, the zebrafish developed into females. We also show that Tet3 is involved in PGC development. Notably, we find that DNA methylome reprogramming during adult zebrafish sex transition is similar to the reprogramming during the sex differentiation from 9 dpf PGCs to sperm. Furthermore, inhibiting DNMTs activity can prevent the female-to-male sex transition, suggesting that methylation reprogramming is required for zebrafish sex transition. In summary, DNA methylation plays important roles in zebrafish germline development and sexual plasticity.Copyright © 2021. Published by Elsevier B.V.

基金：
the Ministry of Science and Technology of China (Grant No. 2018YFC1003300), the National Natural Science Foundation of China (Grant Nos. 31630040, 81871171, 31871454 and 31671540), the CAS Funding (Grant No. QYZDY-SSWSMC016), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB38020500), and the Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 292020000011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2023]版：
大类 | 2 区 生物学
小类 | 3 区 遗传学
第一作者：
第一作者机构： [1]CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences /China National Center for Bioinformation, Beijing 100101, China [3]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences /China National Center for Bioinformation, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]University of Chinese Academy of Sciences, Beijing 100049, China [4]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academyof Sciences, Beijing 100101, China [7]State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Center for Life Sciences, School ofLife Sciences, Yunnan University, Kunming 650091, China [8]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式(GB/T 7714)：
Wang Xinxin,Ma Xin,Wei Gaobo,et al.The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish[J].Genomics、Proteomics & Bioinformatics.2021,doi:10.1016/j.gpb.2020.10.004.
APA：
Wang Xinxin,Ma Xin,Wei Gaobo,Ma Weirui,Zhang Zhen...&Liu Jiang.(2021).The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish.Genomics、Proteomics & Bioinformatics,,
MLA：
Wang Xinxin,et al."The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish".Genomics、Proteomics & Bioinformatics .(2021)

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