Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP, which was measured using an oscillometric device. The serum klotho concentration was measured using an enzyme-linked immunosorbent assay and logarithmically transformed. Of the 716 participants (mean age: 51.9 ± 12.6 years), 467 (65.2%) were women. The median serum klotho concentration was 381.8 pg/mL. The serum klotho concentration did not significantly differ between patients with and without hypertension (P > 0.05) and between those with and without arterial stiffness (cfPWV ≥ 10 m/s) (P > 0.05). After adjusting for confounders, the serum klotho concentration was not significantly associated with the peripheral or central BP (P > 0.05) and cfPWV (P > 0.05). Our data indicated that the serum klotho concentration was not associated with BP or cfPWV in the general Chinese population.
基金：
the National Natural Science Foundation of China (Grants
81460084, 81660072, and 81860084), the Young and Middle-aged Academic Leader Training Foundation of Yunnan
Province (2015HB056), the Medical Academic Leader Foundation of Yunnan Provincial Bureau of Health
(D-201672), the Innovation Team of Hypertension Prevention and Treatment of Dali University (ZKPY2019304),
and the Ten-thousand Talents Program of Yunnan Province.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Department of Gerontology, The First Affiliated Hospital of Dali University, Jiashibo Road 32, Dali, 671000, Yunnan Province, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liang Wan-Ying,Wang Li-Hong,Wei Jian-Hang,et al.No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population[J].Scientific reports.2021,11(1):2374.doi:10.1038/s41598-021-82258-5.
APA：
Liang Wan-Ying,Wang Li-Hong,Wei Jian-Hang,Li Qing-Lu,Li Qi-Yan...&Li Li-Hua.(2021).No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population.Scientific reports,11,(1)
MLA：
Liang Wan-Ying,et al."No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population".Scientific reports 11..1(2021):2374
