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Vascular endothelial growth factor-loaded poly-lactic-co-glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats

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机构： [1]Department of Neurology, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China. [2]Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan. [3]Centre for Stem Cell and Regenerative Medicine, Liaocheng People's Hospital, Liaocheng, China. [4]College of Pharmacy, Liaocheng University, Liaocheng, China. [5]Department of Neuroimmune Laboratory, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China. [6]Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming, China.

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Vascular endothelial growth factor (VEGF) had neuroprotective effects on dopaminergic (DA) neurons. In order to overcome the gastrointestinal digestion and bioaccessibility, VEGF was encapsulated with poly-lactic-co-glycolic acid nanospheres (NS) in order to prevent the VEGF degradation until its release. The caudal administration of VEGF and NS encapsulated VEGF at different doses (1.0, 10.0, and 100.0 ng/ml) on the rats with Parkinson's disease lesion was evaluated. Intravenous injected VEGF at the dose of 1 ng/ml displayed the strongest neuroprotective effect than other groups as well as the stereotaxic group. The NS encapsulated with VEGF can pass through blood-brain barrier and protect the DA neurons. There was no significant difference between intravenous injection method and stereotaxic method, while the first method is simpler and convenient. Injection of NS encapsulated with VEGF may become a valuable neurorescuing therapeutic approach for Parkinson's disease.© 2020 John Wiley & Sons A/S.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 4 区生化与分子生物学 4 区药物化学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区生化与分子生物学 4 区药物化学

第一作者：

第一作者机构： [1]Department of Neurology, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China.

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通讯作者：

通讯机构： [1]Department of Neurology, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China. [6]Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming, China. [*1]Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming, China. [*2]Department of Neurology, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China

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