机构：[1]Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands.[2]Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.[3]Environmental Health Sciences Division, School of Public Health, University of California, Berkeley, California, USA.[4]Qujing Center for Diseases Control and Prevention, Qujing, Yunnan, China.[5]Department of Community, Environment & Policy, Mel & Enid Zuckerman College of Public Health, University of Arizona, Arizona, USA.[6]Division of Epidemiology and Biostatistics, School of Public Health, University of Hong Kong, Hong Kong, China.[7]Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), Kunming, Yunnan, China.[8]Saw Swee Hock School of Public Health, National University of Singapore, Singapore.[9]Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.[10]School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.[11]Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, Oregon, USA.
Lung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified.We aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer.Using a population-based case-control study of lung cancer among 1,015 never-smoking female cases and 485 controls, we examined the association between exposure to 43 household air pollutants and lung cancer. Pollutant predictions were derived from a comprehensive exposure assessment study, which included methylated polycyclic aromatic hydrocarbons (PAHs), which have never been directly evaluated in an epidemiological study of any cancer. Hierarchical clustering and penalized regression were applied in order to address high colinearity in exposure variables.The strongest association with lung cancer was for a cluster of 25 PAHs [odds ratio (OR): 2.21; 95% confidence interval (CI): 1.67, 2.87 per 1 standard deviation (SD) change], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individual observed OR (5.42; 95% CI: 0.94, 27.5). A positive association with nitrogen dioxide ([Formula: see text]) was also observed (OR: 2.06; 95% CI: 1.19, 3.49). By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text]) were associated with lung cancer in the multipollutant models.To our knowledge, this is the first study to comprehensively evaluate the association between lung cancer and household air pollution (HAP) constituents estimated over the entire life course. Given the global ubiquity of coal use domestically for indoor cooking and heating and commercially for electric power generation, our study suggests that more extensive monitoring of coal combustion products, including methylated PAHs, may be warranted to more accurately assess health risks and develop prevention strategies from this exposure. https://doi.org/10.1289/EHP4913.
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外文
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出版当年[2019]版：
大类|1 区环境科学与生态学
小类|1 区环境科学1 区公共卫生、环境卫生与职业卫生1 区毒理学
最新[2023]版：
大类|1 区环境科学与生态学
小类|1 区环境科学1 区公共卫生、环境卫生与职业卫生1 区毒理学
第一作者：
第一作者机构：[1]Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands.[*1]Institute for Risk Assessment Sciences (IRAS), Utrecht University, P.O. Box 80178, 3508 TD, Utrecht, Netherlands
共同第一作者：
通讯作者：
通讯机构：[1]Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands.[*1]Institute for Risk Assessment Sciences (IRAS), Utrecht University, P.O. Box 80178, 3508 TD, Utrecht, Netherlands
推荐引用方式(GB/T 7714)：
Vermeulen Roel,Downward George S,Zhang Jinming,et al.Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China[J].Environmental health perspectives.2019,127(9):97001.doi:10.1289/EHP4913.
APA：
Vermeulen Roel,Downward George S,Zhang Jinming,Hu Wei,Portengen Lützen...&Lan Qing.(2019).Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China.Environmental health perspectives,127,(9)
MLA：
Vermeulen Roel,et al."Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China".Environmental health perspectives 127..9(2019):97001
环境科学与生态学