机构：[1]Faculty of Environmental Science and Engineering, Kunming University ofScience and Technology, Kunming City 650504, Yunnan Province, China[2]Medical School, Kunming University of Science and Technology, KunmingCity 650504, Yunnan Province, China[3]Department of RehabilitationMedicine, The First Affiliated Hospital of Chengdu Medical College, ChengduCity 610500, Sichuan Province, China[4]Department of Oncology, YunfengHospital, Xuanwei City 655400, Yunnan Province, China
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner regulating the expression of some essential mRNA targets required for the control of tumor cell proliferation and growth, invasion, and chemo-resistance, associating with a poor overall survival and metastasis in various types of human cancers. Therefore, IGF2BP1 has been traditionally regarded as an oncogene and potential therapeutic target for cancers. Nevertheless, a few studies have also demonstrated its tumor-suppressive role. However, the details about the contradictory functions of IGF2BP1 are unclear. The growing numbers of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been identified as its direct regulators, during tumor cell proliferation, growth, and invasion in multiple cancers. Thus, the mechanisms of post-transcriptional modulation of gene expression mediated by IGF2BP1, miRNAs, and lncRNAs in determining the fate of the development of tissues and organs, as well as tumorigenesis, need to be elucidated. In this review, we summarized the tissue distribution, expression, and roles of IGF2BP1 in embryogenesis and tumorigenesis, and focused on modulation of the interconnectivity between IGF2BP1 and its targeted mRNAs or non-coding RNAs (ncRNAs). The potential use of inhibitors of IGF2BP1 and its related pathways in cancer therapy was also discussed.
基金：
This work was supported by The National Natural Science Foundation of
China (81460007), the Cooperative Innovation Center for Old-age Care and
Geriatric Health of Sichuan Province of China (YLZBZ1515), and the Natural
Science Foundation of Sichuan provincial department of education of China
(17A0130).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|1 区医学
小类|2 区血液学2 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|1 区血液学1 区肿瘤学
第一作者：
第一作者机构：[1]Faculty of Environmental Science and Engineering, Kunming University ofScience and Technology, Kunming City 650504, Yunnan Province, China[2]Medical School, Kunming University of Science and Technology, KunmingCity 650504, Yunnan Province, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Xinwei,Zhang Hong,Guo Xiaoran,et al.Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer[J].Journal of hematology & oncology.2018,11(1):88.doi:10.1186/s13045-018-0628-y.
APA：
Huang Xinwei,Zhang Hong,Guo Xiaoran,Zhu Zongxin,Cai Haibo&Kong Xiangyang.(2018).Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer.Journal of hematology & oncology,11,(1)
MLA：
Huang Xinwei,et al."Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer".Journal of hematology & oncology 11..1(2018):88
医学