Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis
机构：[1]Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China[2]Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China[3]Department of Emergency, Affiliated Jintan People’s Hospital of Jiangsu University, Jintan, China[4]Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
The aim of this study was to evaluate the association between CTLA-4 +49 G>A polymorphism and esophageal cancer (EC) susceptibility in a hospital based case-control study and a subsequent meta-analysis. We implemented genotyping analyses for CTLA-4 +49 G>A polymorphism with 629 esophageal squamous cell carcinoma cases and 686 controls in a Chinese Han population. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to identify genotypes of CTLA-4 +49 G>A polymorphism. We first assessed the association between CTLA-4 +49 G>A polymorphism and EC risk in a hospital based case-control study, and then performed a comprehensive meta-analysis to derive a more precise estimation. Our results demonstrated that CTLA-4 +49 G>A polymorphism was not associated with EC risk. This case-control study and further meta-analysis, failed to identify the association between CTLA-4 +49 G>A polymorphism and EC risk. And additional, further well designed studies with large sample sizes and detailed gene-environment data are required.
基金：
Jiang-su University Clinical Medicine Science and Technology Development Fund (JLY201400-12), National Natural Science Foundation of China (81472332, 81341006), Fujian Provin-ce Natural Science Foundation (2013J01126, 2013J05116), Fujian Medical University professor fund (JS12008) and Fujian Province science and technology programmed fund (2012Y0030).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China[*1]Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212000, China
推荐引用方式(GB/T 7714)：
Chao Liu,Yafeng Wang,Heping Jiang,et al.Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis[J].International journal of clinical and experimental medicine.2015,8(10):17664-73.
APA：
Chao Liu,Yafeng Wang,Heping Jiang,Weifeng Tang,Shuchen Chen...&Haiyong Gu.(2015).Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis.International journal of clinical and experimental medicine,8,(10)
MLA：
Chao Liu,et al."Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis".International journal of clinical and experimental medicine 8..10(2015):17664-73
