机构：[1]The Third Military Medical School, Chongqing, China[2]Yunnan Provincial Hospital of Infectious Disease, Kunming, China[3]Center for Infectious Diseases, CPLA Kunming General Hospital, Kunming, China
The most common antiretroviral treatment (ART) received by individuals infected with HIV-1 in China is the combination therapy, comprised of nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). To assess the prevalence of HIV-1 drug resistance and subtypes in Honghe of Yunnan, China, patient plasmas from ART-failed individuals were collected from January 2010 to December 2012. Genotyping was conducted using an in-house assay on patient plasmas. A total of 254 pol sequences were obtained. The prevalence of drug resistance was 47.2% in ART-failed individuals. Of these drug-resistant individuals, 51.7% harbored HIV strains dually resistant to NRTIs and NNRTIs or protease inhibitors (PIs) (34.2% for NNRTIs and 14.2% for NRTIs). Mutations such as M184V, A62V, T69Ins, K103N, Y181C, and G190A were common among the ART-failed individuals. The frequencies of M184V, A62V, and K103N were 20.5%, 11.0%, and 23.6%, respectively. The most common subtypes in Honghe were CRF08_BC (68.50%) and CRF07_BC (12.20%). The subtypes were almost consistent in different time points for one individual. When receiving ART for 6-12 months, the frequency of HIV-1 drug-resistant variants ranked first. This study shows that the high prevalence of HIV drug resistance observed among the ART-failed individuals should be of increasing concern (monitoring of resistance mutations) in ART regions and facilitate developing novel strategies for prevention and control of HIV infection in China.
基金：
National Science Research for the 12th Five-Year Plan (2012ZX10001006 and 2012ZX10001-002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
最新[2023]版：
大类|4 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
第一作者：
第一作者机构：[1]The Third Military Medical School, Chongqing, China[3]Center for Infectious Diseases, CPLA Kunming General Hospital, Kunming, China
通讯作者：
通讯机构：[1]The Third Military Medical School, Chongqing, China[2]Yunnan Provincial Hospital of Infectious Disease, Kunming, China[3]Center for Infectious Diseases, CPLA Kunming General Hospital, Kunming, China[*1]Yunnan Provincial Hospital of Infectious Disease, 28km Shi An Rd., Kunming 650301, China.
推荐引用方式(GB/T 7714)：
Cuixian Yang,Shaomin Yang,Jianjian Li,et al.The Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China[J].AIDS research and human retroviruses.2015,31(8):822-9.doi:10.1089/AID.2014.0348.
APA：
Cuixian Yang,Shaomin Yang,Jianjian Li,Bihui Yang,Jiafa Liu...&Zhongqi Bian.(2015).The Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China.AIDS research and human retroviruses,31,(8)
MLA：
Cuixian Yang,et al."The Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China".AIDS research and human retroviruses 31..8(2015):822-9
