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Research progress on the mechanism of ferroptosis and its role in diabetic retinopathy

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机构： [1]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China [2]Kunming Univ Sci & Technol, Dept Ophthalmol, Affiliated Hosp, Kunming, Peoples R China [3]First Peoples Hosp Yunnan Prov, Dept Ophthalmol, Kunming, Peoples R China [4]Kunming Univ Sci & Technol, Med Sch, Kunming, Peoples R China [5]Kunming Aier Eye Hosp, Dept Ophthalmol, Kunming, Peoples R China

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关键词： ferroptosis diabetic retinopathy cell death glutathione peroxidase 4 reactive oxygen species

摘要：

Ferroptosis is iron-dependent regulatory cell death (RCD). Morphologically, ferroptosis is manifested as mitochondrial atrophy and increased mitochondrial membrane density. Biochemically, ferroptosis is characterized by the depletion of glutathione (GSH), the inactivation of glutathione peroxidase 4 (GPX4), and an increase in lipid peroxides (LPO)and divalent iron ions. Ferroptosis is associated with various diseases, but the relationship with diabetic retinopathy(DR) is less studied. DR is one of the complications of diabetes mellitus and has a severe impact on visual function. The pathology of DR is complex, and the current treatment is unsatisfactory. Therefore, exploring pathogenesis is helpful for the clinical treatment of DR. This paper reviews the pathological mechanism of ferroptosis and DR in recent years and the involvement of ferroptosis in the pathology of DR. In addition, we propose problems that need to be addressed in this research field. It is expected to provide new ideas for treating DR by analyzing the role of ferroptosis in DR.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

最新[2023]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

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出版当年[2022]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.2 出版当年[2022版] 5.9 出版当年五年平均 6.055 出版前一年[2021版] 3.9 出版后一年[2023版]

第一作者：

第一作者机构： [1]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China [2]Kunming Univ Sci & Technol, Dept Ophthalmol, Affiliated Hosp, Kunming, Peoples R China [3]First Peoples Hosp Yunnan Prov, Dept Ophthalmol, Kunming, Peoples R China [4]Kunming Univ Sci & Technol, Med Sch, Kunming, Peoples R China

通讯作者：

通讯机构： [2]Kunming Univ Sci & Technol, Dept Ophthalmol, Affiliated Hosp, Kunming, Peoples R China [3]First Peoples Hosp Yunnan Prov, Dept Ophthalmol, Kunming, Peoples R China

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