机构：[1]Department of Medical Imaging, Southern Central Hospital of Yunnan Province (The First People’s Hospital of Honghe State), Mengzi, Yunan, China[2]Department of MRI, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China医技片磁共振科云南省第一人民医院[3]Department of Anesthesiology, Southern Central Hospital of Yunnan Province (The First People’s Hospital of Honghe State), Mengzi, Yunan, China
AIM: To evaluate the diagnostic and differential efficacy of diffusion kurtosis imaging (DKI) histogram analysis for different motor subtypes of Parkinson's disease (PD).MATERIALS AND METHODS: Seventy PD patients including 40 with postural instability and gait disorder (PIGD) and 30 with tremor-dominant (TD) and 36 healthy controls (HC) were enrolled prospectively and underwent MRI examinations. The regions of interest (ROI) in the deep brain nuclei were delineated and features were extracted on the map of mean kurtosis (MK), axial kurtosis (Ka), and radial kurtosis (Kr), respectively. The differences in histogram features between PD patients and HC and between patients with PIGD and TD were compared. The areas under the curve (AUCs) were calculated to evaluate the diagnostic efficacy of all histogram features. The correlations between histogram features and clinical indicators were evaluated.RESULTS: Some DKI histogram features were significantly different between PD patients and HC, and also different between patients with PIGD and TD (all p<0.05). MK of the substantia nigra pars reticulate (SNpr(kurtosis)), Ka of the substantia nigra pars compacta (SNpc) 50 percentile (SNpcP50), and Kr of SNpc 90th percentile showed the highest AUC for distinguishing patients with PIGD from HC. MK-SNpc 10th percentile, Ka-SNpc 25th percentile, and Kr of the head of the caudate nucleus (CN) 90th percentile had the highest AUC for distinguishing patients with TD from HC. MK of the putamen 10th percentile combined with Ka of the bilateral red nucleus RNkurtosis yielded the highest diagnostic performance with an AUC of 0.762 for distinguishing patients with PIGD from TD. Certain DKI histogram features were correlated with Hoehn-Yahr (H&Y) stage, Mini Mental State Examination (MMSE) score, tremor score, and PIGD score (all p<0.05).CONCLUSION: DKI histogram analysis was useful to diagnose and discriminate different motor subtypes of PD. Certain DKI histogram features correlated with clinical indicators.(c) 2023 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.
第一作者机构：[1]Department of Medical Imaging, Southern Central Hospital of Yunnan Province (The First People’s Hospital of Honghe State), Mengzi, Yunan, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of MRI, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China[*1]The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan, China
推荐引用方式(GB/T 7714)：
Wang J.,Bi Q.,Gong W.,et al.Histogram analysis of diffusion kurtosis imaging of deep brain nuclei in Parkinson's disease with different motor subtypes[J].CLINICAL RADIOLOGY.2023,78(12):966-974.doi:10.1016/j.crad.2023.09.008.
APA：
Wang, J.,Bi, Q.,Gong, W.,Zhang, H.,Deng, M....&Wang, B..(2023).Histogram analysis of diffusion kurtosis imaging of deep brain nuclei in Parkinson's disease with different motor subtypes.CLINICAL RADIOLOGY,78,(12)
MLA：
Wang, J.,et al."Histogram analysis of diffusion kurtosis imaging of deep brain nuclei in Parkinson's disease with different motor subtypes".CLINICAL RADIOLOGY 78..12(2023):966-974
