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Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry

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WOS体系：
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收录情况： ◇ SCIE

作者：
Li Hailong[1] * ; Li Qingyang[2] ; Duan Xinwang[3] ; Zhang Shangzhu[2] ; Wang Yanhong[4] ; Xu Jian[5] ; Li Qin[6] ; Wu Lijun[7] ; Wu Zhenbiao[8] ; Yang Min[9] ; Liu Shengyun[10] ; Su Jinmei[11] ; Li Mengtao[12] ; Zeng Xiaofeng[2] ; Gao Xiang[13,14,15] ;
机构： [1]Department of Nutrition, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. [2]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. [3]Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. [4]Department of Epidemiology and Bio-Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [5]Department of Rheumatology, Kunming Medical University First Affiliated Hospital, Kunming, China. [6]Department of Rheumatology, First People's Hospital of Yunnan, Kunming, China. [7]Department of Rheumatology, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China. [8]Department of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi'an, China. [9]Department of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, China. [10]Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [11]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. jinmei.su@cstar.org.cn. [12]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. mengtao.li@cstar.org.cn. [13]Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Shanghai, China. [14]Institute of Nutrition, Fudan University, Shanghai, China. [15]Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
出处：
DOI： 10.1007/s40744-024-00646-5
ISSN：

关键词： Anemia Cross-sectional studies Spondyloarthritis Low body mass index

摘要：
Anemia and malnutrition are recognized indicators of suboptimal physical condition in chronic inflammatory diseases. This study aimed to examine the association between anemia, low body mass index (BMI), and clinical outcomes in axial spondyloarthritis (axSpA).This cross-sectional analysis utilized data from the multicenter ChinaSpA cohort. A total of 4146 participants with axSpA were categorized into four groups based on BMI and hemoglobin levels: those with both anemia and low BMI, those with anemia only, those with low BMI only, and those with neither condition. Logistic regression analyses were performed to analyze the association between anemia, low BMI, inflammation status, functional impairment, and disease activity.Anemia was present in 13.94%, low BMI in 11.99%, and both conditions in 2.15% of axSpA participants. Those with both anemia and low BMI showed significantly higher levels of inflammation (hypersensitive C-reactive protein [hsCRP] 30.60 mg/L vs. 8.44 mg/L), functional impairment (Bath Ankylosing Spondylitis Functional Index [BASFI] 3.80 vs. 2.10), and disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] 4.52 ± 2.04 vs. 3.67 ± 2.21; Ankylosing Spondylitis Disease Activity Score calculated with C-reactive protein [ASDAS_CRP] 3.51 ± 1.10 vs. 2.62 ± 1.21) compared to those without these conditions. After adjusting for sex and age, significant associations were observed between elevated hsCRP levels and the presence of low BMI (odds ratio [OR] 1.44, 95% CI 1.17-1.78), anemia (OR 1.91, 95% CI 1.56-2.32), and their concurrent presence (OR 3.59, 95% CI 2.22-5.80). Similarly, increased BASFI was significantly associated with low BMI (OR 1.57, 95% CI 1.25-1.97), anemia (OR 1.47, 95% CI 1.19-1.80), and their combination (OR 3.11, 95% CI 2.02-4.78).All-cause anemia and low BMI are prevalent complications in patients with axSpA, exhibiting a significant correlation with elevated inflammation status and functional impairment. The simultaneous occurrence of anemia and low BMI particularly exacerbates clinical outcomes, emphasizing the critical role of comprehensive nutritional assessment and management in the therapeutic strategy for axSpA.© 2024. The Author(s).

基金：
Natural Science Foundation of Xinjiang Uygur Autonomous Region (2021D01C136), CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M- 1-005), National High Level Hospital Clinical Research Funding (2022-PUMCH-B-013), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2021- RW320-013), Key Research and Development Program of Xinjiang Uygur Autonomous Region (2022B03002-3).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 风湿病学
JCR分区：
出版当年[2023]版：
Q2 RHEUMATOLOGY
最新[2023]版：
Q2 RHEUMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Nutrition, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Li Hailong,Li Qingyang,Duan Xinwang,et al.Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry[J].RHEUMATOLOGY AND THERAPY.2024,11(2):397-409.doi:10.1007/s40744-024-00646-5.
APA：
Li Hailong,Li Qingyang,Duan Xinwang,Zhang Shangzhu,Wang Yanhong...&Gao Xiang.(2024).Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry.RHEUMATOLOGY AND THERAPY,11,(2)
MLA：
Li Hailong,et al."Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry".RHEUMATOLOGY AND THERAPY 11..2(2024):397-409

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