RAF/MEK/ERK pathway is frequently activated in tumor. Therefore, this study will investigate the function of RUVBL1 (RAF-binding protein) in tongue squamous cell carcinoma (TSCC). Bioinformatics was perGSE13601, and GSE34105 datasets. A total of 672 shared DE-mRNAs were identified in three datasets, and they are regulating metastasis and angiogenesis. Patients with RUVBL1 low expression had high overopposite results were obtained by knocking down RUVBL1. Moreover, overexpression of RUVBL1 logical behavior of TSCC via activating the CRAF/MEK/ERK pathway. This provides molecular mechanisms and perspectives for targeted therapy of the CRAF/MEK/ERK pathway.
基金：
National Natural Science Foundation of China [81860481, 82103049]; High -End Talent Grant of Yunnan Province, China [KH-SWR-QNBJ-2020-002]; Basic Research Special Youth Project of Yunnan Provincial Department of Science and Technology [202201AU070015]; Yunnan Provincial Department of Science and Technology Kunming Medical Joint Special General Project [202201AY070001-233, 202201AY070001-231]; Midwest Orthodontics Research Project of the Youth Clinical Research Fund of the Chinese Stomatological Association [CSA-MWO2021-15]
