机构：[1]The Affiliated Hospital of Kunming University of Science and Technology. Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Yunnan province, Kunming, Yunnan, China内科片外科片呼吸与危重症医学科重症医学科云南省第一人民医院[2]Guangzhou National Laboratory, Bioland, Guangzhou, Guangdong, China[3]State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain unclarified. Here, we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by severity. We found that early and robust SARS-CoV-2-specific CD4+ and CD8+ T cell responses ameliorate disease progression and shortened hospital stay, while delayed and attenuated virus-specific CD8+ T cell responses are prominent severe COVID-19 features. Delayed antiviral antibody generation rather than titer level associates with severe outcomes. Conversely, initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity, demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate counterparts. Moreover, initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection risk. Overall, our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.
基金：
RD Program of Guangzhou National Laboratory (SRPG23-005), National Key Research and Development Program of China (2023YFC2306400), National Key Research and Development Program of China (2022YFC2604104), Ministry of Science and Technology of the P.R. Chin [SRPG23-005]; R&D Program of Guangzhou National Laboratory [2022YFC2604104]; National Key Research and Development Program of China; Ministry of Science and Technology of the P.R. China [81971485, 82271801]; National Natural Science Foundation of China [SRPG22-006]; S&T Program of Guangzhou Laboratory [ZNSA-2020013]; Zhongnanshan Medical Foundation of Guangdong Province [2022B1111070002, 2020B1111330001]; Guangdong Basic and Applied Basic Research Foundation; Emergency Key Program of Guangzhou Laboratory
第一作者机构：[1]The Affiliated Hospital of Kunming University of Science and Technology. Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Yunnan province, Kunming, Yunnan, China[2]Guangzhou National Laboratory, Bioland, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]The Affiliated Hospital of Kunming University of Science and Technology. Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Yunnan province, Kunming, Yunnan, China[2]Guangzhou National Laboratory, Bioland, Guangzhou, Guangdong, China[3]State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Yang Gang,Cao Jinpeng,Qin Jian,et al.Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection[J].SIGNAL TRANSDUCTION AND TARGETED THERAPY.2024,9(1):doi:10.1038/s41392-024-01867-4.
APA：
Yang, Gang,Cao, Jinpeng,Qin, Jian,Mei, Xinyue,Deng, Shidong...&Wang, Zhongfang.(2024).Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection.SIGNAL TRANSDUCTION AND TARGETED THERAPY,9,(1)
MLA：
Yang, Gang,et al."Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection".SIGNAL TRANSDUCTION AND TARGETED THERAPY 9..1(2024)
医学