机构：[1]First Peoples Hosp Honghe City, Dept Neurosurg, Honghe, Yunnan, Peoples R China[2]Third Mil Med Univ, Daping Hosp, State Key Lab Trauma Burn & Combined Injury, Dept Army Occupat Dis,Army Med Univ, Chongqing, Peoples R China[3]PLA 956th Hosp, Dept Neurosurg, 7-2 Shuangyong St, Linzhi 860000, Xizang, Peoples R China[4]Peoples Hosp Hekou Cty, Dept Neurosurg, Hekou, Yunnan, Peoples R China[5]Peoples Hosp Hekou Cty, Dept Neurol, Hekou, Yunnan, Peoples R China[6]Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China
Background: The purpose of this research was to investigate the effect of uric acid on hypertensive intracerebral hemorrhage (HICH) in young and middle-aged hypertensive patients at high altitude. Methods: High-altitude and low-altitude HICH patients were analyzed retrospectively, and the influence of uric acid on hemorrhage was analyzed by the correlations between age and uric acid, between age and hemoglobin, and between uric acid and hemoglobin. The individuals in the high- and low-altitude groups were assigned to a young/middle-aged group and an elderly group, and the correlation between age and uric acid was analyzed. The risk factors for HICH were analyzed by logistic regression analysis. ROC curve analysis was used to investigate the relationship between risk factors and cerebral hemorrhage. Results: Age was negatively correlated with uric acid concentration in patients with HICH at high altitudes but not in patients with HICH at low altitudes. In addition, age was negatively correlated with hemoglobin in patients with HICH at high altitudes but not in patients with HICH at low altitudes. Uric acid was negatively correlated with age in young and middle-aged adults at high altitudes but not in elderly individuals. Diastolic pressure, uric acid and sex were risk factors for HICH in young and middle-aged adults at high altitudes. ROC curve showed that uric acid and diastolic pressure had diagnostic significance. Conclusions: High levels of uric acid is correlated with increased risk of cerebral hemorrhage in young and middle-aged adults with hypertension in high altitude.
基金：
Central government funds for guiding local scientific and technological development [XZ202201YD0028C]; Special Project for Improving Science and Technology Innovation Ability of Army Medical University [2021XJS16]
第一作者机构：[1]First Peoples Hosp Honghe City, Dept Neurosurg, Honghe, Yunnan, Peoples R China[4]Peoples Hosp Hekou Cty, Dept Neurosurg, Hekou, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]First Peoples Hosp Honghe City, Dept Neurosurg, Honghe, Yunnan, Peoples R China[4]Peoples Hosp Hekou Cty, Dept Neurosurg, Hekou, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Lin Chi,Zhang Bo,Zhao Xiaolong,et al.Hyperuricemia as a risk factor for cerebral hemorrhage in young and middle-aged hypertensive patients at high altitude[J].NEUROLOGY ASIA.2024,29(2):293-300.doi:10.54029/2024jyx.
APA：
Lin, Chi,Zhang, Bo,Zhao, Xiaolong,Xu, Donglin,Zong, Taoxi...&Wei, Linjie.(2024).Hyperuricemia as a risk factor for cerebral hemorrhage in young and middle-aged hypertensive patients at high altitude.NEUROLOGY ASIA,29,(2)
MLA：
Lin, Chi,et al."Hyperuricemia as a risk factor for cerebral hemorrhage in young and middle-aged hypertensive patients at high altitude".NEUROLOGY ASIA 29..2(2024):293-300
