机构：[1]Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.[2]Department of Epidemiology and Biostatistics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.[3]Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.[4]Rheumatology & Immunology Department of Shenzhen Children’s Hospital, Shenzhen, China.深圳市康宁医院深圳医学信息中心[5]Department of Rheumatology and Immunology, The First People’s Hospital of Yunnan Province, Kunming, China.内科片风湿免疫科云南省第一人民医院[6]Pediatric Immunology and Rheumatology Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.[7]Department of pediatric rheumatology, immunology, and allergy, The First Hospital of Jilin University, Changchun, Jilin, China.[8]Department of Pediatric Nephrology, Rheumatology and Immunology, Children’s Hospital Affiliated to Shandong University, Jinan Children’s Hospital, Jinan, Shandong, China.[9]Department of Rheumatology and Immunology, Children’s Hospital of Urumqi, No.1 Jiankang Rd., TianShan Distinct, Urumqi, China.[10]Department of Rheumatology Immunology and Allergy, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.[11]Department of Rheumatology and Immunology, Xi’an Children’s Hospital, Xi’an 710068, China.[12]Department of Rheumatology and Immunology, The Affiliated Children’s Hospital, Capital Institute of Pediatrics, 2 Yabao Road, Chaoyang District, 100020 Beijing, China.首都儿科研究所[13]Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China.[14]Department of Rheumatology and Immunology, Children’s Hospital of Nanjing Medical University No. 72 Guangzhou Road, Nanjing 210008 Jiangsu, China.[15]Department of Pediatric Nephrology, Children’s Hospital of Hebei Province affiliated to Hebei Medical University, Shijiazhuang, China.[16]Department of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450046, China.[17]Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.[18]Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004 Liaoning, PR China.中国医科大学附属盛京医院中国医科大学盛京医院[19]Department of Immunology, Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, 100045 Beijing, China.首都医科大学附属北京儿童医院[20]Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.[21]Department of paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, China.[22]Department of paediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.[23]Inner Mongolia Autonomous Region People’s Hospital, Hohhot, China.[24]Guiyang Maternal and Child Health Care Hospital (Guiyang Children’s Hospital), Guiyang, China.[25]Department of Nephrology and Immunology, Children’s Hospital of Soochow University, Suzhou, China.[26]Qilu Children’s Hospital of Shandong University, Jinan, China.[27]Department of Rheumatology & Immunology, Tianjin Children’s Hospital, No. 238 Longyan Road, Beichen District, Tianjin, China.[28]Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Background This study investigates the clinical characteristics and outcomes of pediatric patients with rheumatic diseases infected with COVID-19 in China. Methods We conducted a retrospective analysis of pediatric patients with rheumatic diseases who contracted COVID-19. Data were collected via a comprehensive questionnaire with a 14-day follow-up. Multivariable logistic regression was used to assess severe outcomes, and network analyses evaluated symptom correlations. Results A total of 1070 cases were collected. Fever (88.05%) and cough (62.75%) were the most common symptoms. Cough, nasal congestion, and runny nose exhibited a stronger correlation with each other. A higher incidence of fever reduced the incidence of two single symptoms (nasal congestion [r = -0.833], runny nose [r = -0.762]). Vaccinated children showed a shorter time to negative COVID-19 conversion (7.21 days vs. 7.63 days, p < 0.05) and lower hospitalization rates (p = 0.025). Prolonged symptom duration was associated with older age (OR: 1.07 [1.04-1.11]; p < 0.001) and systemic lupus erythematosus (OR: 1.47 [1.01-2.12]; p = 0.046). Conclusions Pediatric patients with rheumatic diseases exhibited a wide range of clinical symptoms after COVID-19 infection. The infection generally did not lead to severe outcomes in this study. COVID-19 vaccination was associated with reduced hospitalization risk and expediting the time to negativity for virus. Impacts This manuscript demonstrates a comprehensive analysis of the clinical characteristics and outcomes of COVID-19 infection in pediatric patients with rheumatic diseases in China. It provides critical insights into the specific challenges faced by this vulnerable population and offers practical recommendations for improving patient management during periods of increased infectious risk.
基金：
National Key R&D Program of China [2021YFC2702003]; Emergency special project for COVID-19 [2023IITXG26]
第一作者机构：[1]Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Yating,Su Shu,Ma Mingsheng,et al.Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases[J].PEDIATRIC RESEARCH.2024,doi:10.1038/s41390-024-03561-1.
APA：
Wang, Yating,Su, Shu,Ma, Mingsheng,Weng, Ruohang,Zhang, Zhiyong...&Tang, Xuemei.(2024).Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases.PEDIATRIC RESEARCH,,
MLA：
Wang, Yating,et al."Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases".PEDIATRIC RESEARCH .(2024)
