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Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients

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资源类型：
Pubmed体系：
作者：
Qin Shijie[1,2] * ; Yao Xiaohong[3,4] * ; Li Weiwei[1] * ; Wang Canbiao[2] * ; Xu Weijun[1,5] * ; Gan Zhenhua[1,4] * ; Yang Yang[1] ; Zhong Aifang[4,6] ; Wang Bin[4,7] ; He Zhicheng[3,4] ; Wu Jian[1] ; Wu Qiuyue[1] ; Jiang Weijun[1] ; Han Ying[1] ; Wang Fan[1] ; Wang Zhihua[4,8] ; Ke Yuehua[4,9] ; Zhao Jun[1] ; Gao Junyin[10] ; Qu Liang[4,11] ; Jin Ping[2] ; Guan Miao[2] ; Xia Xinyi[1,4] ; Bian Xiuwu[3,4] ;
机构： [1]Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 210002, Nanjing, Jiangsu, China. [2]Laboratory for Comparative Genomics and Bioinformatics, College of Life Science, Nanjing Normal University, 210046, Nanjing, Jiangsu, China. [3]Institute of Pathology, Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Southwest Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, China. [4]Joint Expert Group for COVID-19, Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, 430100, Wuhan, Hubei, China. [5]Department of Gastroenterology, Jinling Hospital, Nanjing University School of Medicine, 210002, Nanjing, Jiangsu, China. [6]Medical Technical Support Division, the 904th Hospital, 213003, Changzhou, Jiangsu, China. [7]Department of Gastroenterology, Daping Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, China. [8]Department of Laboratory Medicine and Blood Transfusion, the 907th Hospital, 350702, Nanping, Fujian, China. [9]Chinese PLA Center for Disease Control and Prevention, 100070, Beijing, China. [10]Pulmonary and Critical Care Medicine, Yancheng No.1 People's Hospital, 224000, Yancheng, Jiangsu, China. [11]Department of Laboratory Medicine, 920 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, 650032, Kunming, Yunnan, China.
出处：
DOI： 10.1038/s41419-023-05814-z

摘要：
How does SARS-CoV-2 cause lung microenvironment disturbance and inflammatory storm is still obscure. We here performed the single-cell transcriptome sequencing from lung, blood, and bone marrow of two dead COVID-19 patients and detected the cellular communication among them. Our results demonstrated that SARS-CoV-2 infection increase the frequency of cellular communication between alveolar type I cells (AT1) or alveolar type II cells (AT2) and myeloid cells triggering immune activation and inflammation microenvironment and then induce the disorder of fibroblasts, club, and ciliated cells, which may cause increased pulmonary fibrosis and mucus accumulation. Further study showed that the increase of T cells in the lungs may be mainly recruited by myeloid cells through ligands/receptors (e.g., ANXA1/FPR1, C5AR1/RPS19, and CCL5/CCR1). Interestingly, we also found that certain ligands/receptors (e.g., ANXA1/FPR1, CD74/COPA, CXCLs/CXCRs, ALOX5/ALOX5AP, CCL5/CCR1) are significantly activated and shared among lungs, blood and bone marrow of COVID-19 patients, implying that the dysregulation of ligands/receptors may lead to immune cell's activation, migration, and the inflammatory storm in different tissues of COVID-19 patients. Collectively, our study revealed a possible mechanism by which the disorder of cell communication caused by SARS-CoV-2 infection results in the lung inflammatory microenvironment and systemic immune responses across tissues in COVID-19 patients.© 2023. The Author(s).

基金：
Thanks to Key Foundation of Wuhan Huoshenshan Hospital (2020 [18]), Key Research & Development Program of Jiangsu Province (BE2018713), Medical Innovation Project of Logistics Service (18JS005), Jiangsu Provincial Key Medical Talent (ZDRCA2016097), 333 high-level talents of Jiangsu Province (BRA2019338), Foundation of Jiangsu Population Association (JSPA2019017, JSPA2019020), Jiangsu Provincial Association for Maternal and Child Health Studies Commissioned Research Project Funding (JSFY202005), and Jiangsu Commission of Health Geriatric Health Research Project (LK2021025).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
第一作者：
第一作者机构： [1]Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 210002, Nanjing, Jiangsu, China. [2]Laboratory for Comparative Genomics and Bioinformatics, College of Life Science, Nanjing Normal University, 210046, Nanjing, Jiangsu, China.
共同第一作者：
通讯作者：
通讯机构： [1]Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 210002, Nanjing, Jiangsu, China. [3]Institute of Pathology, Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Southwest Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, China. [4]Joint Expert Group for COVID-19, Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, 430100, Wuhan, Hubei, China.
推荐引用方式(GB/T 7714)：
Qin Shijie,Yao Xiaohong,Li Weiwei,et al.Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients[J].Cell Death & Disease.2023,14(4):286.doi:10.1038/s41419-023-05814-z.
APA：
Qin Shijie,Yao Xiaohong,Li Weiwei,Wang Canbiao,Xu Weijun...&Bian Xiuwu.(2023).Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients.Cell Death & Disease,14,(4)
MLA：
Qin Shijie,et al."Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients".Cell Death & Disease 14..4(2023):286

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