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Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ 卓越：梯队期刊

作者：
Pan Chongge[1,2] * ; Hou Yali[3] * ; Hou Yanting[1,2] * ; Wang Ruizhen[4,5,6] * ; Qian Meiyu[1,2] * ; Bai Xue[4,5] ; Liang Maodi[1,2] ; Wang Jingzhou[1,2] ; Liu Jie[1,2] ; Wei Qianqian[1,2] ; Pan Ziyan[1,2] ; Wang Ting[1,2] ; Hu Chenyu[1,2] ; Xiang Kun[7] ; Yang Chun[4,5] ; Wang Cuizhe[1,2] ; Chen Hua[4,5,6,8] ; Zhang Jun[1,2] ;
机构： [1]Medical College of Shihezi University, Shihezi, Xinjiang 832000, China [2]Laboratory of Xinjiang Endemic and Ethic Diseases of Shihezi University, Shihezi, Xinjiang 832000, China. [3]Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. [4]China National Center for Bioinformation, Beijing 100101, China [5]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China. [7]The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650223, China [8]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
出处：
DOI： 10.1016/j.jgg.2024.11.011
ISSN：

关键词： Obesity miR-548ab GULP1 and SLC25A21 Glucose metabolism T2DM

摘要：
Dysregulation of microRNA (miRNA) expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus (T2DM). Identifying differentially expressed miRNAs and their roles in regulating glucose metabolism will provide a theoretical foundation for the molecular mechanisms underlying obesity-induced T2DM. Here, we perform a genome-wide association study involving 5 glycolipid metabolism traits in 1783 Kazakh and 1198 Uyghur individuals to identify miRNAs associated with fasting plasma glucose (FPG) levels. A miR-548ab mimic and inhibitor are administered to hepatocytes and adipocytes, as well as obese and diabetic mice, to determine miR-548ab-related downstream signalling pathways. The effects of miR-548ab on glucose metabolism are validated using the glucose tolerance test and insulin tolerance test. Collectively, these results indicate that miR-548ab is significantly associated with FPG levels and obesity-related T2DM in both Kazakh and Uyghur populations. The miR-548ab-GULP1/SLC25A21-GLUT4 network exerts regulatory effects on glucose metabolism, obesity, and T2DM, positioning it as a candidate risk factor, potential diagnostic marker, and therapeutic target for obesity-induced T2DM. Additionally, through evolutionary analysis, the authentic variants or haplotypes of GULP1 and SLC25A21 are categorized according to their genetic susceptibility to T2DM. The miR-548ab inhibitor shows beneficial effects in obese and diabetic mice.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

基金：
This work was supported by the Natural Science Foundation of China (82160156, 82260162, and 32370669), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB38040200), the Tianshan Talent Project in Xinjiang Autonomous Region (2023TSYCCX0116 and 2023TSYCQNTJ0032), and the Scientific and Technological Research Project of Xinjiang Production and Construction Corps (2022ZD001, 2021AB028, 2022AB022, 2023AB057, and 2023ZD037). We thank the Agricultural Science and Technology Innovation Program (ASTIP).
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外文
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出版当年[2025]版：
无
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 遗传学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Medical College of Shihezi University, Shihezi, Xinjiang 832000, China [2]Laboratory of Xinjiang Endemic and Ethic Diseases of Shihezi University, Shihezi, Xinjiang 832000, China.
共同第一作者：
通讯作者：
通讯机构： [1]Medical College of Shihezi University, Shihezi, Xinjiang 832000, China [2]Laboratory of Xinjiang Endemic and Ethic Diseases of Shihezi University, Shihezi, Xinjiang 832000, China. [4]China National Center for Bioinformation, Beijing 100101, China [5]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China. [8]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
推荐引用方式(GB/T 7714)：
Pan Chongge,Hou Yali,Hou Yanting,et al.Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM[J].Journal Of Genetics And Genomics.2025,52(2):231-244.doi:10.1016/j.jgg.2024.11.011.
APA：
Pan Chongge,Hou Yali,Hou Yanting,Wang Ruizhen,Qian Meiyu...&Zhang Jun.(2025).Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM.Journal Of Genetics And Genomics,52,(2)
MLA：
Pan Chongge,et al."Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM".Journal Of Genetics And Genomics 52..2(2025):231-244

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