机构：[1]Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.[2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.[3]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650201, P.R. China.[4]National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650107, P.R. China.[5]State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.[6]University of Chinese Academy of Sciences, Beijing 100101, China.[7]The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650034, P.R. China.云南省第一人民医院[8]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650201, China.[9]Beijing Key Laboratory for Genetics of Birth Defects, Beijing 100045, China.[10]Department of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.[11]Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.[12]Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA.
Neocortex expansion has a concerted relationship with folding, underlying evolution of human cognitive functions. However, molecular mechanisms underlying this significant evolutionary process remains unknown. Here, using tree shrew as an outgroup of primates, we identify a new regulator CCNB1IP1, which acquired its expression before the emergence of primates. Following the evolution of cis-regulatory elements, the CCNB1IP1 expression has steadily increased over the course of primate brain evolution, mirroring the gradual increase of neocortex. Mechanistically, we elucidated that CCNB1IP1 expression can cause an increase in neural progenitors through shortening G1 phase. Consistently, the CCNB1IP1 knock-in mouse model exhibited traits associated with enhanced learning and memory abilities. Together, our study reveals how changes in CCNB1IP1 expression may have contributed to the gradual evolution in primate brain.
基金：
L.S. is supported by the Pioneer Hundred Talents Program of the Chinese Academy of
Sciences and the Yunnan Revitalization Talent Support Program Young Talent Project.
This study was supported by grants from the National Key Research and Development
Program of China (2021YFF0702700) to L.S. and BY.M, National Natural Science
Foundation of China (32170630), Yunnan Applied Basic Research Projects
(202201AS070043 and 202401AS070072), Science and Technology Major Project of
Science and Technology of Department of Yunnan Province (202102AA100057),
Spring City Project from Kunming Science and Technology Bureau (2022SCP007) to
L.S., The joint special project for basic research between the Yunnan Provincial Science
and Technology Department and Kunming Medical University (202101AY070001-269)
to K.X. NHGRI (HG011641), and National Science Foundation (EF-2204761) to
S.V.Y.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.[2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.[3]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650201, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.[2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.[4]National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650107, P.R. China.
推荐引用方式(GB/T 7714)：
Hu Ting,Kong Yifan,Tan Yulian,et al.Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates[J].Biorxiv : The Preprint Server For Biology.2024,doi:10.1101/2024.12.08.627376.
APA：
Hu Ting,Kong Yifan,Tan Yulian,Ma Pengcheng,Wang Jianhong...&Shi Lei.(2024).Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates.Biorxiv : The Preprint Server For Biology,,
MLA：
Hu Ting,et al."Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates".Biorxiv : The Preprint Server For Biology .(2024)
