Background: Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined. Methods: Bidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations. Results: Forward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.0013). The estimated effect value (beta = -0.0440) suggests that for every 1-unit increase in tea intake, there is a 0.044-unit decrease in SUA levels. However, there is no reverse causality between SUA and tea intake (p = 0.2824). No causal relationship was found between the consumption of different types of tea and risk of elevated SUA levels (p > 0.05). Conclusion: Although this bidirectional MR study provided evidence of a causal relationship between tea intake and SUA levels, however, due to limitations associated with the sample size and strength of instrumental variables, a definite conclusion was not possible.
基金：
National Natural Science Foundation of China [81960863, 81960870, 82160901, 82260928]; Construction Project of Yunnan Provincial Fund for Medical Research Center [202102AA310006]; Construction Project of National Traditional Chinese Medicine Clinical Research Base [131]; Construction Project for the focal branch of National Traditional Chinese Medicine [85]; Expert Workstation of zhangxuan in Yunnan Province [202305AF150175]; Funding of Yunnan Applied Basic Research Projects-Union Foundation [2019FF002 (-082), 2019FF002 (-031), 202101AZ070001-072]; Construction Project Funding of University Key Laboratories in Yunnan Province [2018TGZ01]; Funding of Yunnan Provincial Health Science and Technology Plan [2018NS0045, 2018NS0046]
第一作者机构：[1]Yunnan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Rheumatol, Kunming, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Yunnan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Rheumatol, Kunming, Peoples R China[2]Yunnan Prov Hosp Tradit Chinese Med, Yunnan Prov Clin Med Res Ctr Rheumatism TCM, Kunming, Peoples R China
推荐引用方式(GB/T 7714)：
Yan Weitian,Wang Xingqiang,Peng Zining,et al.A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels[J].INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES.2025,28(2):doi:10.1111/1756-185X.70128.
APA：
Yan, Weitian,Wang, Xingqiang,Peng, Zining,Deng, Qian,Zhu, Mengyuan...&Peng, Jiangyun.(2025).A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,28,(2)
MLA：
Yan, Weitian,et al."A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels".INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 28..2(2025)
