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Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis

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机构： [1]Department of Anesthesiology, Kunming Children’s Hospital, Yunnan, China. [2]Department of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Yunnan, China. [3]Wenzhou Medical University, Wenzhou, China. [4]Department of Comprehensive Pediatrics, Kunming Children’s Hospital, Yunnan, China. [5]Department of Cardiac Surgery, The First People’s Hospital of Kunming, Yunnan, China. [6]Surgical Intensive Care Unit, Kunming Children’s Hospital, Yunnan, China. [7]Department of Anesthesiology, Kunming City Maternal and Child Health Hospital, Yunnan, China. [8]Yu-zhen Zhang and Run-wei Ma contributed equally to this work and share first authorship

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关键词： Systemic immune-inflammation index Adolescent obesity NHANES Inflammation

摘要：

Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various chronic diseases in the future. The systemic immune-inflammation index (SII) serves as an indicator of inflammation and immune response. This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, including 5,676 participants. A multivariate logistic regression model, Generalized Additive Models (GAM), and subgroup analysis were used to examine the relationship between obesity and SII. The multivariate logistic regression results revealed a significant positive correlation between log SII and adolescent obesity (1.254 [1.024-1.537]). Furthermore, the risk of obesity increased with higher quartiles of SII. Subgroup analysis and interaction tests showed that this positive association persisted across various factors, including female gender, race (Non-Hispanic White and Mexican American), non-hyperlipidemia, normal white blood cell count, and PIR < 1. Additionally, a U-shaped relationship between log SII and obesity was observed, with a turning point at 6.410. The findings suggest that an increase in the systemic immune-inflammation index is significantly associated with obesity in adolescents. However, further validation through large-scale prospective studies is needed.© 2025. The Author(s).

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最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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第一作者机构： [1]Department of Anesthesiology, Kunming Children’s Hospital, Yunnan, China.

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通讯机构： [1]Department of Anesthesiology, Kunming Children’s Hospital, Yunnan, China. [6]Surgical Intensive Care Unit, Kunming Children’s Hospital, Yunnan, China.

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