机构：[1]Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.[2]Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.[3]Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.[4]Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.[5]Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Chongqing 400016, China.[6]Department of Rehabilitation and Pain Medicine, The Ninth People's Hospital of Chongqing, Chongqing 400700, China.[7]Impactys Foundation for Biomedical Research, San Diego, CA 92121.[8]Department of Cardiothoracic Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 363880, China.外科片心脏大血管外科胸外科云南省第一人民医院[9]Center for Translational Research in Clinical Medicine, School of Medicine, Kunming University of Science and Technology, Kunming 650500, China.[10]Department of Cardiothoracic Surgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 363880, China.外科片心脏大血管外科胸外科云南省第一人民医院
Atherosclerosis and vessel wall trauma induce vascular smooth muscle cell (VSMC) phenotypic modulation, leading to plaque cap growth and postintervention restenosis. Our systems biology approach identified RNA binding protein, mRNA processing factor (RBPMS) as a conserved, VSMC-specific gene associated with VSMC modulation in atherosclerosis. RBPMS gene expression positively correlates with VSMC contractile markers in human and murine atherosclerotic arteries as well as in two vascular injury models during the postinjury intimal hyperplasia phase. RBPMS promotes contractile VSMC differentiation, reduces plaque cap development in high-fat diet-fed apolipoprotein E-null (ApoE-/-) murine atherosclerotic arteries, and inhibits intimal hyperplasia. Mechanistically, the RBPMS protein interacts with the myocardin (MYOCD) pre-mRNA and enhances MYOCD_v3/MYOCD_v1 transcript balance through alternative exon 2a splicing. RBPMS promotes the VSMC contractile phenotype and reduces their fibroproliferative activity in a MYOCD_v3a-dependent manner. RBPMS enhances Myocd_v3/Myocd_v1 transcript balance in both atherosclerotic and injured vessels. RBPMS may inhibit VSMC-driven plaque cap development and intervention-induced restenosis.
基金：
We would like to thank Dr. Hector Hernandez-Vargas
(Genomics Consulting, 69500 Bron, France) for his technical assistance with the
bioinformatics pipeline and associated analyses. This work was supported by
the National Natural Science Foundation of China (81960095 and 81871369).
The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
第一作者机构：[1]Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.[5]Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Chongqing 400016, China.[9]Center for Translational Research in Clinical Medicine, School of Medicine, Kunming University of Science and Technology, Kunming 650500, China.[10]Department of Cardiothoracic Surgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 363880, China.
推荐引用方式(GB/T 7714)：
Du Jianlin,Yuan Xin,Wang Jiajia,et al.The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury[J].Proceedings Of The National Academy Of Sciences Of The United States Of America.2025,122(9):e2415933122.doi:10.1073/pnas.2415933122.
APA：
Du Jianlin,Yuan Xin,Wang Jiajia,Zhang Lujun,Tan Fangyan...&Sun Yang.(2025).The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury.Proceedings Of The National Academy Of Sciences Of The United States Of America,122,(9)
MLA：
Du Jianlin,et al."The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury".Proceedings Of The National Academy Of Sciences Of The United States Of America 122..9(2025):e2415933122
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