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Multi-Scale and Multi-Level Feature Assessment Framework for Classification of Parkinson's Disease State From Short-Term Motor Tasks

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机构: [1]Univ Sheffield, Sheffield S10 2TN, South Yorkshire, England [2]Yunnan Univ, Kunming 650106, Yunnan, Peoples R China [3]Yunnan First Peoples Hosp, Kunming, Peoples R China
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关键词: Motors Feature extraction Diseases Sensors Electronic mail Monitoring Hands Gyroscopes Frequency-domain analysis Data mining Decomposition disease recognition feature fusion healthcare wearables system machine learning multi-dimensional parkinson's disease

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Objective: Recent quantification research on Parkinson's disease (PD) integrates wearable technology with machine learning methods, indicating a strong potential for practical applications. However, the effectiveness of these techniques is influenced by environmental settings and is hardly applied in real-world situations. This paper aims to propose an effective feature assessment framework to automatically rate the severity of PD motor symptoms from short-term motor tasks, and then classify different PD severity levels in the real world. Methods: This paper identified specific PD motor symptoms using a novel feature-assessment framework at both segment-level and sample-level. Features were selected after calculating SHapley Additive exPlanation(SHAP) value, and verified by different machine learning methods with appropriate parameters. This framework has been verified on real-world data from 100 PD patients performing Unified Parkinson's Disease Rating Scale(UPDRS)-recommended short motor tasks, each task lasting 20-50 seconds. Results: The sensitivity for recognizing motor fluctuations reached 88% in tremor recognition. Additionally, LightGBM achieved the highest accuracy for early detection(92.59%) and achieved 71.58% in fine-grained severity classification using 31 selected features. Conclusion: This paper reports the first effort to assess multi-level and multi-scale features for automatic quantification of motor symptoms and PD severity levels. The proposed framework has been proven effective in assessing key PD information for recognition during short-term tasks. Significance: The explanatory analysis of digital features in this study provides more prior knowledge for PD self-assessment in a free-living environment.

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大类 | 2 区 医学
小类 | 2 区 工程:生物医学
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Q2 ENGINEERING, BIOMEDICAL

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第一作者机构: [1]Univ Sheffield, Sheffield S10 2TN, South Yorkshire, England
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