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Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders

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收录情况： ◇ 自然指数

作者：
Yang Mao[1,2,3] * ; Zhao Yuhao[1,2,3] * ; Li Chen[5] * ; Weng Xiaoling[2,3] * ; Li Zhizhen[6] * ; Guo Wu[5] ; Jia Wenning[1,2,3] ; Feng Feiling[6] ; Hu Jiaming[7] ; Sun Haonan[8] ; Wang Bo[9] ; Li Huaifeng[10] ; Li Ming[11] ; Wang Ting[2,3] ; Zhang Wei[2,3] ; Jiang Xiaoqing[6] ; Zhang Zongli[7] ; Liu Fubao[8] ; Hu Hai[9] ; Wu Xiangsong[10] ; Gu Jianfeng[11] ; Yang Guocai[12] ; Li Guosong[13] ; Zhang Hui[14] ; Zhang Tong[15] ; Zang Hong[16] ; Zhou Yan[17] ; He Min[1] ; Yang Linhua[1] ; Wang Hui[1] ; Chen Tao[1] ; Zhang Junfeng[1,4] ; Chen Wei[1] ; Wu Wenguang[1] ; Li Maolan[1,2,3] ; Gong Wei[10] ; Lin Xinhua[5] ; Liu Fatao[2,3] ; Liu Yun[2,3] ; Liu Yingbin[1,2,3] ;
机构： [1]Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China [2]Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer, Shanghai 200127, China [3]State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai 200127, China [4]Department of General Surgery, Central Hospital of Shanghai Jiading District, Shanghai 201800, China [5]Network and Information Center, Shanghai Jiao Tong University, Shanghai 200240, China [6]Department of Biliary Surgery, Third Affiliated Hospital of Naval Military Medical University, Shanghai 200438, China [7]Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China [8]Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China [9]Center of Gallstone Disease, East Hospital Affiliated to Tongji University, Shanghai 200120, China [10]Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China [11]Department of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu 215500, China [12]Department of Radiology, Qinghai Provincial People’s Hospital, Xining, Qinghai 810007, China [13]Department of General Surgery, The Second People’s Hospital of Baoshan, Baoshan, Yunnan 678000, China [14]Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China [15]Department of Hepatobiliary Hospital, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, China [16]Department of General Surgery, The First People’s Hospital of Nantong, Nantong, Jiangsu 226001, China [17]Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Pudong District, Shanghai 200127, China
出处：
DOI： 10.1016/j.ccell.2025.02.011
ISSN：

摘要：
Gallbladder cancer (GBC) frequently mimics gallbladder benign lesions (GBBLs) in radiological images, leading to preoperative misdiagnoses. To address this challenge, we initiated a prospective, multicenter clinical trial (ChicCTR2100049249) and proposed a multimodal, non-invasive diagnostic model to distinguish GBC from GBBLs. A total of 301 patients diagnosed with gallbladder-occupying lesions (GBOLs) from 11 medical centers across 7 provinces in China were enrolled and divided into a discovery cohort and an independent external validation cohort. An artificial intelligence (AI)-based integrated model, GBCseeker, is created using cell-free DNA (cfDNA) genetic signatures, radiomic features, and clinical information. It achieves high accuracy in distinguishing GBC from GBBL patients (93.33% in the discovery cohort and 87.76% in the external validation cohort), reduces surgeons' diagnostic errors by 56.24%, and reclassifies GBOL patients into three categories to guide surgical options. Overall, our study establishes a tool for the preoperative diagnosis of GBC, facilitating surgical decision-making.Copyright © 2025 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (no. 32130036), the Open Project of the National Center for Translational Medicine (Shanghai) (no. NRCTM(SH)-2021-04), the Clinical Technology Innovation Project of Shanghai Shen-kang Hospital Development Center (no. SHDC12021101), the Basic Research Project of Science and Technology Commission of Shanghai Municipality (no. 23DZ2202800), the Key Program of Shanghai Science and Technology Commission (YDZX20193100004049), the Shanghai Rising-Star Program (23QA1408500), the Young Talents Program of Shanghai Municipal Health Commission (2022YQ061), the Shanghai Municipal Health Commission Grants (202140050), the ’Jiao Tong University Star’ Medical-Engineering Cross Fund of Shanghai Jiao Tong University (YG2022ZD006),and the Basic Research Project of Shanghai Cancer Institute and Shanghai Runda Rongjia Biotechnology Co., Ltd (SYXF0120022383).
语种：
外文
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出版当年[2025]版：
无
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China [2]Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer, Shanghai 200127, China [3]State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai 200127, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China [2]Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer, Shanghai 200127, China [3]State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai 200127, China
推荐引用方式(GB/T 7714)：
Yang Mao,Zhao Yuhao,Li Chen,et al.Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders[J].Cancer Cell.2025,43(3):398-412.e4.doi:10.1016/j.ccell.2025.02.011.
APA：
Yang Mao,Zhao Yuhao,Li Chen,Weng Xiaoling,Li Zhizhen...&Liu Yingbin.(2025).Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders.Cancer Cell,43,(3)
MLA：
Yang Mao,et al."Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders".Cancer Cell 43..3(2025):398-412.e4

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