机构：[1]Department of Hematology, The First Afliated Hospital of Guangxi Medical University, Nanning, China [2]Department of Hematology, The First Afliated Hospital of Guangxi Medical University, Nanning, China [3]Department of Hematology, Liuzhou Worker’s Hospital, Liuzhou, China [4]Shanghai Institute of Hematology, RuiJin Hospital Medical School, Shanghai JiaoT, Shanghai, China [5]Department of Pediatrics, The First Afliated Hospital of Guangxi Medical University, Nanning, China [6]Medical Center of Hematology, Xinqiao Hospital of Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, China [7]Department of Hematology, 923rd Hospital of the People’s Liberation Army, Nanning, China [8]Department of Hematology, The Afliated Hospital of Youjiang Medical College, Baise, China [9]Department of Hematology, Hainan Provincial People’s Hospital, Haikou, China [10]Department of Hematology, Maoming People’s Hospital, Maoming, China [11]Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Afliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China [12]Department of Hematology, Yulin Red Cross Hospital, Yulin, China [13]Department of Hematology, The Afliated Hospital of Guilin Medical College, Guilin, China [14]The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China [15]Department of Pediatrics, Wuzhou People’s Hospital, Wuzhou, China [16]Department of Hematology, The First People’s Hospital of Yunnan Province, Kunming, China 内科片血液内科云南省第一人民医院[17]Department of Hematology, 920th Hospital of Joint Logistics Support Force, Kunming, China [18]Department of Hematology, Liuzhou People’s Hospital, Liuzhou, China [19]Department of Pediatrics, 923rd Hospital of the People’s Liberation Army, Nanning, China [20]Gobroad Research Center, Shanghai, China [21]M.D. Anderson Cancer Center, Houston, TX [22]Department of Stem Cell Transplantation & Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston [23]Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX [24]Peking University People’s Hospital, Beijing, China [25]Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing,
Background: Graft failure (GF) and graft-versus-host disease (GVHD) remain major barriers to successful outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with transfusion dependent thalassemia (TDT). We
had reported an encouraging outcome of allo-HSCT in a single center study, which the 3-year event-free survival (EFS) was
97% in patients with TDT transplanted with HLA-matched sibling donors. We aimed to conrm this result and to assess the
outcomes of allo-HSCT for TDT patients transplanted with alternative donor.
医学