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The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies

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收录情况： ◇ 自然指数

作者：
Yu Chen[1] * ; Wu Chanyuan[1] * ; Jin Shangyi[1] * ; Peng Liying[1] ; Duan Xinwang[2] ; Yang Pinting[3] ; Wei Wei[4] ; Wang Yanhong[5] ; Li Mucong[1] ; Zhou Shuang[1] ; Liu Shengyun[6] ; Wang Jing[7] ; Li Hongbin[8] ; Zheng Zhaohui[9] ; Shi Xiaofei[10] ; Xu Jian[11] ; Wang Yongfu[12] ; Zhao Jiuliang[1] ; Xu Dong[1] ; Yin Peng[13] ; Zeng Xiaofeng[1] ; Li Mengtao[1] ; Wang Qian[1,14] ;
机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Science & Technology, Beijing, China [2]Department of Rheumatology, the Second Affiliated Hospital of Nanchang University, Nanchang, China [3]Department of Rheumatology, the First Hospital of China Medical University, Shenyang,China [4]Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin, China [5]Department [6]Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [7]Department of Rheumatology, the First People’s Hospital of Yunnan Province, Kunming, China [8]Department of Rheumatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China [9]Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China [10]Department of Rheumatology, the First Affiliated Hospital of Henan University of Science & Technology, Luoyang, China [11]Department of Rheumatology, the First Affiliated Hospital of Kunming Medical University, Kunming, China [12]Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Baotou, China [13]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China [14]State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China
出处：
DOI： 10.1016/j.jaad.2025.06.062
ISSN：

摘要：
Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases with variable long-term outcomes.To determine the prognosis of IIM.This multicenter, prospective cohort study included Chinese patients with IIM. We calculated the standardized mortality ratios (SMRs) adjusted for age and sex, analyzed causes of death, and identified risk factors for all-cause mortality using a multivariable Cox proportional hazards model.A total of 4,534 patients were included, with 2,902 dermatomyositis, 592 polymyositis, 927 anti-synthetase syndrome (ASS), and 113 immune-mediated necrotizing myositis (IMNM). 510 patients died with a median follow-up time of 46 months. The overall SMR was 6.2 (95% CI 5.7-6.7). Cumulative survival rates at 1, 3 and 10 years were 92.6%, 88.6% and 80.5%, respectively. Leading causes of death included interstitial lung diseases (18.8%), malignancies (18.8%), cardiovascular diseases (CVD, 18.8%), and infections (18.6%), which shifted over time (from ILD/infection to malignancies/CVD). Risk factors for mortality included male, lymphopenia, high serum ferritin, anti-MDA-5, anti-TIF1γ, and anti-Ro 52 antibodies.Underestimation of ASS and IMNM.IIM patients had significantly higher mortality than general population, with variable causes of death and distinct risks based on myositis-specific antibodies. MSAs-based classification may provide deeper insights into pathogenesis and management of IIM.Copyright © 2025. Published by Elsevier Inc.

基金：
This study was supported by the Chinese National Key Technology R&D Program, Ministry of Science and Technology (2024YFC2510304, 2022YFC2504603), CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-005, 2023-I2M-C&T B-035, 2021-I2M-1-005 ) and National High Level Hospital Clinical Research Funding (2022-PUMCH-C-020, 2022-PUMCH-D-009, 2022-PUMCH-A-107), and State Key Laboratory Special Fund 2060204.
语种：
外文
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出版当年[2025]版：
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最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 皮肤病学
第一作者：
第一作者机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Science & Technology, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Science & Technology, Beijing, China [14]State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
Yu Chen,Wu Chanyuan,Jin Shangyi,et al.The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies[J].Journal Of The American Academy Of Dermatology.2025,doi:10.1016/j.jaad.2025.06.062.
APA：
Yu Chen,Wu Chanyuan,Jin Shangyi,Peng Liying,Duan Xinwang...&Wang Qian.(2025).The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.Journal Of The American Academy Of Dermatology,,
MLA：
Yu Chen,et al."The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies".Journal Of The American Academy Of Dermatology .(2025)

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