目的：本研究旨在探讨清肺饮联合阿奇霉素治疗支原体肺炎患儿时，患儿炎症标志物水平的变化及治疗效果。方法：研究选取了122名支原体肺炎患儿，随机分为观察组(61例，接受清肺饮联合阿奇霉素治疗)和对比组(61例，仅接受阿奇霉素治疗)。对比分析两组患儿在疗程结束后的咳嗽持续时间、发热时长、肺部啰音消退时间，以及治疗前后TNF-α、hs-CRP、IL-6等炎症标志物的水平和治疗效果。结果：观察组在咳嗽缓解、退热、肺部啰音消除等方面较对比组表现出更快的改善(P α、hs-CRP、IL-6等炎症指标水平显著低于对比组(P Objective: The aim of this study was to investigate the changes in the levels of inflammatory markers and the therapeutic effects of children with Mycoplasma pneumonia when Qingfei Decoction combined with azithromycin was used to treat the children. Methods: One hundred and twenty-two children with Mycoplasma pneumonia were selected for the study and randomly divided into the observation group (61 cases, treated with Qingfei Decoction combined with azithromycin) and the comparison group (61 cases, treated with azithromycin only). We compared and analyzed the duration of cough, duration of fever, time of lung rales subsiding at the end of the treatment course, as well as the levels of inflammatory markers such as TNF-α, hs-CRP, IL-6 and the therapeutic effect before and after the treatment in the two groups of children. Results: The observation group showed faster improvement in cough relief, fever reduction, and elimination of lung rales than the comparison group (P α, hs-CRP, and IL-6 in the observation group were significantly lower than those in the comparison group after treatment (P Mycoplasma pneumonia, which can effectively alleviate the clinical symptoms and reduce the level of inflammatory markers, and is worthy of popularization and application in clinical practice.