机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China昆明医科大学附属第一医院[2]Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China
Increasing evidence has revealed that the activation of the JNK pathway participates in apoptosis of nerve cells and neurological function recovery after traumatic brain injury. However, which genes in the JNK family are activated and their role in traumatic brain injury remain unclear. Therefore, in this study, in situ end labeling, reverse transcription-PCR and neurological function assessment were adopted to investigate the alteration of JNK1, JNK2 and JNK3 gene expression in cerebral injured rats, and their role in cell apoptosis and neurological function restoration. Results showed that JNK3 expression significantly decreased at 1 and 6 hours and 1 and 7 days post injury, but that JNK1 and JNK2 expression remained unchanged. In addition, the number of apoptotic nerve cells surrounding the injured cerebral cortex gradually reduced over time post injury. The Neurological Severity Scores gradually decreased over 1, 3, 5, 14 and 28 days post injury. These findings suggested that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.
第一作者机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China[*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China[2]Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China[*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China[*2]Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China
推荐引用方式(GB/T 7714)：
Jiang Long,Li Cai,Jintao Li,et al.JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury☆[J].NEURAL REGENERATION RESEARCH.2013,8(16):1491-1499.doi:10.3969/j.issn.1673-5374.2013.16.006.
APA：
Jiang Long,Li Cai,Jintao Li,Lei Zhang,Haiyang Yang&Tinghua Wang.(2013).JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury☆.NEURAL REGENERATION RESEARCH,8,(16)
MLA：
Jiang Long,et al."JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury☆".NEURAL REGENERATION RESEARCH 8..16(2013):1491-1499
