机构：[1]Department of Orthopaedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China昆明医科大学附属第一医院[2]Department of Cardiology,Yunnan First People’s Hospital,Kunming 650032,Yunnan Province,China外科片云南省第一人民医院内科片心血管内科
BACKGROUND:There is lack of an effective measuring means to diagnose deep venous thrombosis (DVT) in clinic.KLF2 and KLF4 are down-expressed at prethrombotic state,which may be served as predictive molecular markers to diagnose DVT.OBJECTIVE:To explore the feasibility of KLF2 and KLF4 as molecular markers to prediagnose DVT in rats.METHODS:Totally 90 rats were obtained from 100 rats to establish traumatic DVT models and divided into the prethrombotic,thrombosis crest-time and non-thrombosis groups.The remained 10 rats served as control group.Rat blood was collected at each time point,and the expressions of KLF2 and KLF4 were detected by real-time PCR.RESULTS AND CONCLUSION:The KLF2 and KLF4 mRNA expressions in the prethrombotic group and thrombosis crest-time group were lower than that of the control group.However,the KLF2 and KLF4 mRNA expressions in the non-thrombosis group was higher than that of the control group.Therefore,KLF2 and KLF4 may be candidate molecular markers for prediagnosis of DVT in rats.
基金：
National Natural
Science Foundation
of China, No.
30960389
语种：
外文
第一作者：
第一作者机构：[1]Department of Orthopaedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
通讯作者：
通讯机构：[2]Department of Cardiology,Yunnan First People’s Hospital,Kunming 650032,Yunnan Province,China[*1]Asscicote Chief physician,Department of Cardiology,Yunnan First People’s Hospital,Kunming 650032,Yunnan Province,China
推荐引用方式(GB/T 7714)：
Yao Li-qing,Dai Yao-jun,Zhao Xue-ling,et al.血液中抗凝基因KLF2、KLF4表达与深静脉血栓形成的预测[J].Chinese Journal of Tissue Engineering Research.2011,15(07):1327-1330.doi:10.3969/j.issn.1673-8225.2011.07.042.
APA：
Yao Li-qing,Dai Yao-jun,Zhao Xue-ling,Zhang Yu-bing,Ning Ya...&Li Wen.(2011).血液中抗凝基因KLF2、KLF4表达与深静脉血栓形成的预测.Chinese Journal of Tissue Engineering Research,15,(07)
MLA：
Yao Li-qing,et al."血液中抗凝基因KLF2、KLF4表达与深静脉血栓形成的预测".Chinese Journal of Tissue Engineering Research 15..07(2011):1327-1330
