机构：[1]Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University,[2]Department of Hepatobiliary Surgery, Shanghai Public Health Centre, Shanghai,[3]Department of Hepatobiliary and Pancreatic Surgical Oncology, First Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing,[4]Department of Molecular Diagnosis, Clinical Medical College, Yangzhou University, Jiangsu, Departments of Hepatobiliary Surgery,[5]Foshan First People’s Hospital,[6]Southern Hospital, affiliated to Southern Medical University, Guangdong,[7]Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, Departments of Hepatobiliary Surgery,[8]Fujian Cancer Hospital,[9]Fujian Provincial Hospital,[10]LongYan First Hospital, affiliated to Fujian Medical University, Fujian,[11]Department of Hepatobiliary Surgery, No. 940 Hospital of Joint Logistics Support Force, Gansu,[12]Department of Hepatobiliary Surgery, Inner Mongolia People’s Hospital, Inner Mongolia,[13]Department of Hepatobiliary Surgery, First Affiliated Hospital of Kunming Medical University, Yunnan,昆明医科大学附属第一医院[14]Department of Hepatobiliary Surgery, Affiliated Hospital of Binzhou Medical College,[15]Qingdao Sixth People’s Hospital, Shandong,[16]Department of General Surgery,Wenzhou People’s Hospital,[17]Second Affiliated Hospital ofWenzhou Medical University, Zhejiang,[18]Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
Background Hepatic vein tumour thrombus (HVTT) is a major determinant of survival outcomes for patients with hepatocellular carcinoma (HCC). An Eastern Hepatobiliary Surgery Hospital (EHBH)-HVTT model was established to predict the prognosis of patients with HCC and HVTT after liver resection, in order to identify optimal candidates for liver resection. Methods Patients with HCC and HVTT from 15 hospitals in China were included. The EHBH-HVTT model with contour plot was developed using a non-linear model in the training cohort, and subsequently validated in internal and external cohorts. Results Of 850 patients who met the inclusion criteria, there were 292 patients who had liver resection and 198 who did not in the training cohort, and 124 and 236 in the internal and external validation cohorts respectively. Contour plots for the EHBH-HVTT model were established to predict overall survival (OS) rates of patients visually, based on tumour diameter, number of tumours and portal vein tumour thrombus. This differentiated patients into low- and high-risk groups with distinct long-term prognoses in the liver resection cohort (median OS 34 center dot 7 versus 12 center dot 0 months; P < 0 center dot 001), internal validation cohort (32 center dot 8 versus 10 center dot 4 months; P = 0 center dot 002) and external validation cohort (15 center dot 2 versus 6 center dot 5 months; P = 0 center dot 006). On subgroup analysis, the model showed the same efficacy in differentiating patients with HVTT in peripheral and major hepatic veins, the inferior vena cava, or in patients with coexisting portal vein tumour thrombus. Conclusion The EHBH-HVTT model was accurate in predicting prognosis in patients with HCC and HVTT after liver resection. It identified optimal candidates for liver resection among patients with HCC and HVTT, including tumour thrombus in the inferior vena cava, or coexisting portal vein tumour thrombus.
基金：
Key Project of Natural Science Foundation of ChinaNational Natural Science Foundation of China [81730097]; Science Fund for Creative Research GroupsScience Fund for Creative Research Groups [81521091]; National Key Basic Research Programme '973 project' [2015CB554000]
第一作者机构：[1]Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University,[3]Department of Hepatobiliary and Pancreatic Surgical Oncology, First Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University,[*1]Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200433 China
推荐引用方式(GB/T 7714)：
Zhang X-P,Wang K.,Gao Y-Z,et al.Prognostic model for identifying candidates for hepatectomy among patients with hepatocellular carcinoma and hepatic vein invasion[J].BRITISH JOURNAL OF SURGERY.2020,107(7):865-877.doi:10.1002/bjs.11524.
APA：
Zhang, X-P,Wang, K.,Gao, Y-Z,Wei, X-B,Lu, C-D...&behalf of the Chinese National Research Cooperative Group for Diagnosis and Treatment of Hepatocellular Carcinoma with Tumour Thrombus.(2020).Prognostic model for identifying candidates for hepatectomy among patients with hepatocellular carcinoma and hepatic vein invasion.BRITISH JOURNAL OF SURGERY,107,(7)
MLA：
Zhang, X-P,et al."Prognostic model for identifying candidates for hepatectomy among patients with hepatocellular carcinoma and hepatic vein invasion".BRITISH JOURNAL OF SURGERY 107..7(2020):865-877
医学