Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population
机构：[1]Cell Biology and Genetics Department, Kunming Medical University,China[2]School of Medicine, Yunnan University, China[3]The First Affiliated Hospital of Kunming Medical University, Kunming Medical University, China昆明医科大学附属第一医院
Objective: Prolylcarboxypeptidase (PRCP) is a negative regulator of the pressor actions of the renin-angiotensin-aldosterone system. It is also involved in the kallikrein-kinin system. This gene has an important role in blood pressure (BP) regulation. Methods: A case-control study was performed for 615 Yi participants (303 cases and 312 controls) from a remote mountainous area in Yunnan Province of China. For the PRCP gene, 11 tag single-nucleotide polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The PRCP gene rs12290550 was associated with the occurrence of essential hypertension (EH) and BP traits. Logistic regression analysis indicated that the rs12290550 T allele was significantly linked to the risk of EH (odds ratio (OR) = 1.85, 95% confidence interval (CI) 1.44-2.39, p = 0.2 x 10(-5)). Under Bonferroni correction, the H7 TAGCACTAACA haplotype containing the risk allele rs12290550 T increased the risk of EH (OR = 4.53, 95% CI 2.29-8.93, p = 0.2x10(-5)). Conclusions: The findings of this study demonstrate the strong association of the PRCP gene with EH. rs12290550 may be a useful genetic predictor of EH in the Yi minority.
基金：
Hundred-Talent Program of Kunming Medical University [60117190439]; Foundation of the Education Department of Yunnan Province [2018JS151]
第一作者机构：[1]Cell Biology and Genetics Department, Kunming Medical University,China[2]School of Medicine, Yunnan University, China[*1]Cell Biology and Genetics Department, Kunming Medical University, #1168 N. West Chunrong Road, Kunming, Yunnan Province 650500, China.
通讯作者：
通讯机构：[1]Cell Biology and Genetics Department, Kunming Medical University,China[2]School of Medicine, Yunnan University, China[*1]Cell Biology and Genetics Department, Kunming Medical University, #1168 N. West Chunrong Road, Kunming, Yunnan Province 650500, China.[*2]School of Medicine, Yunnan University, #2 N. Cuihu Road, Kunming, Yunnan Province 650091, China.
推荐引用方式(GB/T 7714)：
Wu Yanrui,Yang Hongju,Xiao Chunjie.Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population[J].JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM.2020,21(2):doi:10.1177/1470320320919586.
APA：
Wu, Yanrui,Yang, Hongju&Xiao, Chunjie.(2020).Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM,21,(2)
MLA：
Wu, Yanrui,et al."Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population".JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 21..2(2020)
