机构：[a]Dept of Anaesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, Szczecin, Poland[b]Dept of Critical Care, Cliniques Universitaires St Luc, UCL, Brussels, Belgium[c]Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Augsburg, Germany[d]Dept of Intensive Care, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain[e]Dept of Anesthesia & Perioperative Medicine, Mayo Clinic, Rochester, MN, USA[f]Service d'Anesthésie et de Réanimation, Aix Marseille Université, APHM, Hôpital Nord, Marseille, France[g]Department of Medicine, Medical College of Wisconsin, Milwaukee,WI, USA[h]Department of Intensive Care and Evidence-Based Medicine, Hospital Alcides Carneiro, Petrópolis Medical School, Petrópolis, Brazil[i]Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany[j]Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - <= 50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (<= 50 = 25.2%: 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients <= 50 years (493% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved.
第一作者机构：[a]Dept of Anaesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, Szczecin, Poland
通讯作者：
通讯机构：[j]Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium[*1]Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
推荐引用方式(GB/T 7714)：
Katarzyna Kotfis,XavierWittebole,Ulrich Jaschinski,et al.A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit[J].JOURNAL OF CRITICAL CARE.2019,51:122-132.doi:10.1016/j.jcrc.2019.02.015.
APA：
Katarzyna Kotfis,XavierWittebole,Ulrich Jaschinski,Jordi Solé-Violán,Rahul Kashyap...&Jean-Louis Vincent.(2019).A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit.JOURNAL OF CRITICAL CARE,51,
MLA：
Katarzyna Kotfis,et al."A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit".JOURNAL OF CRITICAL CARE 51.(2019):122-132
