机构：[1]Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.昆明医科大学附属第一医院[2]Public Technical Service Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650032, Yunnan, China.[3]Kunming Biological Diversity Regional Center of Large Apparatus and Equipments, Chinese Academy of Sciences, Kunming 650032, Yunnan, China.[4]Department of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming 650032, Yunnan, China.昆明医科大学附属第一医院[5]Yunnan Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.[6]Kunming Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.[7]School of Stomatology, Kunming Medical University, Kunming 650500, Yunnan, China.[8]Department of Reproductive Gynecology, the First People’s Hospital of Yunnan Province, Kunming 650031, Yunnan, China.外科片妇科云南省第一人民医院
Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features. Results A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (<= 49 years of age), female sex, and proximal tumour location. Conclusions This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis.
基金：
This work was supported by grants from Yunnan Applied Basic Research
Projects-Union Foundation of Kunming Medical University [2017FE467(−
132)], the National Natural Science Foundation of China (81960504 and
3171101074), Yunling Scholar (YLXL20170002), Key Science and Technology
Planning Project of Kunming Science and Technology Bureau, Reproductive
and Genetic Technology Innovation Team of Kunming Medical University
(CXTD201708), the Hundred-Talent Program of Kunming Medical University
(60118260104) and Doctoral Research Intial Funding of the First Affiliated
Hospital of Kunming Medical University (2017BS003).
第一作者机构：[1]Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.[5]Yunnan Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.[6]Kunming Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.
共同第一作者：
通讯作者：
通讯机构：[4]Department of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming 650032, Yunnan, China.[5]Yunnan Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.[6]Kunming Engineering Technology Center of Digestive Disease, Kunming 650032, Yunnan, China.
推荐引用方式(GB/T 7714)：
Jiang Liu,Li Tang,Jinhua Yi,et al.Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer[J].BMC GASTROENTEROLOGY.2019,19(1):doi:10.1186/s12876-019-1086-x.
APA：
Jiang Liu,Li Tang,Jinhua Yi,Guimei Li,Youwang Lu...&Kunhua Wang.(2019).Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer.BMC GASTROENTEROLOGY,19,(1)
MLA：
Jiang Liu,et al."Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer".BMC GASTROENTEROLOGY 19..1(2019)
