机构：[1]Central Lab, Liver Disease Research Center, the Second People’s Hospital of Yunnan Province, Kunming, 650203,Yunnan, China[2]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy ofSciences & Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China[3]Clinical Laboratoryof the Second People’s Hospital of Yunnan Province, Kunming, 650203, Yunnan, China[4]State Key Laboratory ofGenetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Instituteof Zoology, Chinese Academy of Sciences, Kunming, 650223, China[5]Kunming College of Life Science, Universityof Chinese Academy of Sciences, Kunming, 650204, China[6]The First Affiliated Hospital of Kunming MedicalUniversity, Kunming, Yunnan Province, 650000, China
Mitochondrial abnormality is frequently reported in individuals with hepatitis B virus (HBV) infection, but the associated hosts' mitochondrial genetic factors remain obscure. We hypothesized that mitochondria may affect host susceptibility to HBV infection. In this study, we aimed to detect the association between chronic HBV infection and mitochondrial DNA in Chinese from Yunnan, Southwest China. A total of 272 individuals with chronic HBV infection (CHB), 310 who had never been infected by HBV (healthy controls, HC) and 278 with a trace of HBV infection (spontaneously recovered, SR) were analysed for mtDNA sequence variations and classified into respective haplogroups. Haplogroup frequencies were compared between HBV infected patients, HCs and SRs. Haplogroup D5 presented a higher frequency in CHBs than in HCs (P = 0.017, OR = 2.87, 95% confidence interval [CI] = (1.21-6.81)) and SRs (P = 0.049, OR = 2.90, 95% CI = 1.01-8.35). The network of haplogroup D5 revealed a distinct distribution pattern between CHBs and non-CHBs. A trend of higher viral load among CHBs with haplogroup D5 was observed. Our results indicate the risk potential of mtDNA haplogroup D5 in chronic HBV infection in Yunnan, China.
基金：
Viral Hepatitis and Related Liver Disease Research Innovation Team of Yunnan Province [2015HC019]; Health Research Institution Project of Yunnan Province [2014NS038, 2014NS039, 2016NS180, 2017NS125, 2017NS126]; Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Fund [2017FE468, 2015FB081]; CAS-TWASChinese Academy of Sciences
第一作者机构：[1]Central Lab, Liver Disease Research Center, the Second People’s Hospital of Yunnan Province, Kunming, 650203,Yunnan, China
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推荐引用方式(GB/T 7714)：
Li Xiao,Zhou Tai-Cheng,Wu Chang-Hui,et al.Correlations between mitochondrial DNA haplogroup D5 and chronic hepatitis B virus infection in Yunnan, China[J].SCIENTIFIC REPORTS.2018,8:doi:10.1038/s41598-018-19184-6.
APA：
Li, Xiao,Zhou, Tai-Cheng,Wu, Chang-Hui,Tao, Li-Lin,Bi, Rui...&Wei, Jia.(2018).Correlations between mitochondrial DNA haplogroup D5 and chronic hepatitis B virus infection in Yunnan, China.SCIENTIFIC REPORTS,8,
MLA：
Li, Xiao,et al."Correlations between mitochondrial DNA haplogroup D5 and chronic hepatitis B virus infection in Yunnan, China".SCIENTIFIC REPORTS 8.(2018)
