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Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients

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机构： [1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [2]Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [3]Department of Breast Surgery, Chongqing Cancer Institute, Chongqing, China [4]Department of Breast and Neck Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China [5]Department of Breast Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China [6]Department of Breast Surgery, Sichuan Cancer Hospital & Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Sichuan Province, China [7]Department of Breast Surgery, Gan Su Province Tumor Hospital, Gansu Province, China [8]Department of Breast Surgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Province, China [9]Department of Breast Surgery, Guizhou People's Hospital, Guizhou Province, China [10]Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi Province, China [11]Department of Breast Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan Province, China [12]Department of Breast Surgery, West China Hospital of Sichuan University, Sichuan Province, China [13]Breast Surgery, The First Hospital of Kunming, Yunnan Province, China [14]Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fouth Military Medical University, Xi'an, Shaanxi Province, China [15]Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, China [16]Department of General Surgery, The First Affiliated Hospital of The Medical College, Shihezi University, Xinjiang Province, China [17]Department of Gastrointestinal/Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi Province, China [18]Breast Surgery, Yunnan Cancer Hospital & Third Affiliated Hospital of Kunming Medical University, Yunnan Province, China [19]Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China [20]Mammary Department, The Third People's Hospital of Shaanxi Province, China [21]Surgical Oncology, General Hospital of Ningxia Medical University, Ningxia Province, China

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BACKGROUND AND PURPOSE: Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Western China. METHODS: We retrospectively collected data from the Western China Clinical Cooperation Group and assessed associations between clinicopathologic factors and histological tumor grade in 8619 female breast cancer patients. Patients were divided into two groups: Group I (tumor grade I/II) and Group II (tumor grade III). Univariable analysis and multivariable logistic regression models were used to analyze the relationships between clinicopathologic factors and tumor grade. RESULTS: Patients presenting with positive axillary lymph nodes, large tumor size (>2 cm), lymphovascular invasion, hormone receptor negativity, human epidermal growth factor receptor 2 (HER-2) positivity, and triple negativity tended to have an increased risk of a high tumor grade. However, the number of pregnancies or births was inversely correlated with the risk of a high tumor grade. In addition, patients presenting with grade III tumors were more likely to receive aggressive treatment, such as adjuvant chemotherapy, anti-HER-2 therapy, and level III axillary lymph node dissection. CONCLUSIONS: Our results suggested that several clinicopathologic factors were associated with high tumor grade of breast cancer patients in Western China.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

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出版当年[2017]版：

Q3 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 4.5 最新[2023版] 4.2 最新五年平均 3.071 出版当年[2017版] 3.201 出版当年五年平均 3.025 出版前一年[2016版] 3.138 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

通讯作者：

通讯机构： [1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [2]Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [20]Mammary Department, The Third People's Hospital of Shaanxi Province, China [21]Surgical Oncology, General Hospital of Ningxia Medical University, Ningxia Province, China [*1]Mammary Department, The Third People's Hospital of Shaanxi Province, No.309 West Yanta Road, Xi'an, 710061, Shaanxi, China [*2]Oncological Surgery, General Hospital of Ningxia Medical University Tumor Hospital, No.804 Shengli South Street, Xingqing District, Yinchuan, Ningxia, 750004, China [*3]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China

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