机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.昆明医科大学附属第一医院[2]Department of Neurosurgery, First People’s Hospital of Kunming, Kunming, Yunnan 650032, China.
Objective Hyperbaric oxygen (HBO) is an emerging complementary alternative medical approach in glioma treatment. However, its mode of action is unknown, so this was investigated in the present study. Methods We constructed an intracranial glioma model of congenic C57BL/6J mice. Glioma growth under HBO stimulation was assessed by bioluminescent imaging and magnetic resonance imaging. Flow cytometry assessed direct effects of HBO on reactive oxygen species (ROS) signaling of transplanted glioma cells and organs, and quantified mature T cells and subgroups in tumors, the brain, and blood. Results HBO promoted the growth of transplanted GL261-Luc glioma in the intracranial glioma mouse model. ROS signaling of glioma cells and brain cells was significantly downregulated under HBO stimulation, but thymus ROS levels were significantly upregulated. CD3+ T cells were significantly downregulated, while both Ti/Th cells (CD3+CD4+) and Ts/Tc cells (CD3+CD8+) were inhibited in tumors of the HBO group. The percentage of regulatory T cells in Ti/Th (CD3+CD4+) cells was elevated in the tumors and thymuses of the HBO group. Conclusion HBO induced ROS signaling in the thymus, inhibited CD3+ T cell generation, and facilitated malignant glioma cell growth in vivo in the intracranial glioma mouse model.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2017]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.[*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Rd, Wuhua District, Kunming 650032, China.
通讯作者：
通讯机构：[1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.[*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Rd, Wuhua District, Kunming 650032, China.
推荐引用方式(GB/T 7714)：
Wang Yong-Gang,Long Jiang,Shao Dong-Chuan,et al.Hyperbaric oxygen inhibits production of CD3+T cells in the thymus and facilitates malignant glioma cell growth[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2018,46(7):2780-2791.doi:10.1177/0300060518767796.
APA：
Wang, Yong-Gang,Long, Jiang,Shao, Dong-Chuan&Song, Hai.(2018).Hyperbaric oxygen inhibits production of CD3+T cells in the thymus and facilitates malignant glioma cell growth.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,46,(7)
MLA：
Wang, Yong-Gang,et al."Hyperbaric oxygen inhibits production of CD3+T cells in the thymus and facilitates malignant glioma cell growth".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 46..7(2018):2780-2791
