详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

miR-203 Suppresses Bladder Cancer Cell Growth and Targets Twist1

39| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Urology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, P.R. China [2]Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China

出处：

DOI：

ISSN：

关键词： miR-203 Bladder cancer (BCa) Proliferation Invasion

摘要：

miR-203 is an epigenetically silenced tumor-suppressive microRNA in tumors. This study was designed to investigate the effects of miR-203 on the proliferation, migration, invasion, and apoptosis of bladder cancer (BCa) cells. The expression levels of miR-203 in BCa tissues, normal adjacent tissues, and BCa cell lines were detected. BCa cells were transfected with miR-203 mimic and inhibitor to investigate the effect of miR-203 on cell functions and the epithelial-mesenchymal transition (EMT). Cotransfection with miR-203 inhibitor and shRNA of the predicted target gene Twist1 (si-Twist1) was performed to investigate the target relationship of miR-203 and Twist1. The effects of knockdown of Twist1 on cell functions were also investigated. The expression of miR-203 was significantly reduced in BCa tissues and cells, in comparison with the control. miR-203 mimic significantly reduced cell viability, invasion, migration, and EMT, and enhanced cell apoptosis. On the contrary, miR-203 inhibitor showed the opposite results. However, the administration of si-Twist1 cancelled the effect of miR-203 inhibitor on cell proliferation, apoptosis, invasion, and migration. These demonstrated that miR-203 may function as a tumor-suppressive microRNA in BCa by negatively targeting Twist1. Both Twist1 and miR-203 might be explored as potential targets for studying the mechanism related to BCa pathogenesis and therapy.

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q3 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2 最新[2023版] 3.1 最新五年平均 3.143 出版当年[2017版] 2.858 出版当年五年平均 1.74 出版前一年[2016版] 4.634 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Urology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, P.R. China

通讯作者：

通讯机构： [2]Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China [*1]Department of Urology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Wuhua District, Kunming, Yunnan 650032, P.R. China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver [2]sp1促进a549细胞增殖、emt、侵袭和血管生成的研究 [3]MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1 [4]MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5 [5]miR-583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1 [6]miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2. [7]Interleukin-22 Promotes Osteosarcoma Cell Proliferation and Invasion via STAT3 Activation [8]ProNGF siRNA inhibits cell proliferation and invasion of pancreatic cancer cells and promotes anoikis [9]MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4 [10]RNA interference influenced the proliferation and invasion of XWLC05 lung cancer cells through inhibiting aquaporin 3